TY - JOUR
T1 - Antibiotics
T2 - Conflict and communication in microbial communities
AU - Schlatter, Daniel C.
AU - Kinkel, Linda L.
PY - 2014/7
Y1 - 2014/7
N2 - We lack insight into the dynamics of antibiotic inhibitory and resistance phenotypes and their roles in mediating interactions among microbial species in natural environments. Antibiotics can act as weapons, mediating antagonistic interactions, or signals, mediating a broader range of antagonistic, neutral, manipulative, or synergistic interactions. Both the role of antibiotics and the interactions they mediate are critical to the coevolutionary dynamics of interacting populations. Fitness tradeoffs constrain the capacity for individual bacterial populations to be efficient at resource use, highly inhibitory to other microbes, and broadly resistant to antibiotics at the same time. Unraveling the phenotypic characteristics of interacting microbial populations provides guidance for discovering antibiotics, managing microbial communities, and identifying factors that maintain antibiotic resistance in these populations.
AB - We lack insight into the dynamics of antibiotic inhibitory and resistance phenotypes and their roles in mediating interactions among microbial species in natural environments. Antibiotics can act as weapons, mediating antagonistic interactions, or signals, mediating a broader range of antagonistic, neutral, manipulative, or synergistic interactions. Both the role of antibiotics and the interactions they mediate are critical to the coevolutionary dynamics of interacting populations. Fitness tradeoffs constrain the capacity for individual bacterial populations to be efficient at resource use, highly inhibitory to other microbes, and broadly resistant to antibiotics at the same time. Unraveling the phenotypic characteristics of interacting microbial populations provides guidance for discovering antibiotics, managing microbial communities, and identifying factors that maintain antibiotic resistance in these populations.
UR - http://www.scopus.com/inward/record.url?scp=84903939646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903939646&partnerID=8YFLogxK
U2 - 10.1128/microbe.9.282.1
DO - 10.1128/microbe.9.282.1
M3 - Article
AN - SCOPUS:84903939646
SN - 1558-7452
VL - 9
SP - 282
EP - 288
JO - Microbe
JF - Microbe
IS - 7
ER -