Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil

Vinícius Leobet Lunkes; Alexandre Alberto Tonin; Gustavo Machado; Luis Gustavo Corbellini; Gustavo Nogueira Diehl; Lucila Carboneiro dos Santos; Camila de Sousa Bezerra; Sérgio Santos de Azevedo; Nebson Fernandes Pequeno; Adriana Moraes da Silva; Rudi Weiblen; Eduardo Furtado Flores

doi:10.1590/0103-8478cr20151135

Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil

Translated title of the contribution: Antibodies against vesicular stomatitis virus in horses from southern, midwestern and northeastern Brazilian states

Vinícius Leobet Lunkes, Alexandre Alberto Tonin, Gustavo Machado, Luis Gustavo Corbellini, Gustavo Nogueira Diehl, Lucila Carboneiro dos Santos, Camila de Sousa Bezerra, Sérgio Santos de Azevedo, Nebson Fernandes Pequeno, Adriana Moraes da Silva, Rudi Weiblen, Eduardo Furtado Flores

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Vesicular stomatitis virus (VSV) is the agent of a vesicular disease that affects many animal species and may be clinically confounded with foot-and-mouth disease in ruminant and swine. Horses are especially susceptible to VSV and may serve as sentinels for virus circulation. The present study investigated the presence of neutralizing antibodies against VSV Indiana III (VSIV-3) in serum samples of 3,626 horses from six states in three Brazilian regions: Southern (RS, n = 1,011), Midwest (GO/DF, n = 1,767) and Northeast (PB, PE, RN and CE, n = 848) collected between 2013 and 2014. Neutralizing antibodies against VSIV-3 (titers ≥40) were detected in 641 samples (positivity of 17.7%; CI_95%:16.5-19.0%), being 317 samples from CE (87.3%; CI_95%: 83.4-90.5%); 109 from RN (65.7%; CI_95%: 57.8 -72.7%); 124 from PB (45.4%; CI_95%: 39.4-51.5%); 78 from GO/DF (4.4%; CI_95%: 3.5-5.5%) and nine samples of RS (0.9%; CI_95%: 0.4-1.7%). Several samples from the Northeast and Midwest harbored high neutralizing titers, indicating a recent exposure to the virus. In contrast, samples from RS had low titers, possibly due to a past remote exposure. Several positive samples presented neutralizing activity against other VSV serotypes (Indiana I and New Jersey), yet in lower titers, indicating the specificity of the response to VSIV-3. These results demonstrated a relatively recent circulation of VSIV-3 in northeastern Brazilian States, confirming clinical findings and demonstrating the sanitary importance of this infection.

Translated title of the contribution	Antibodies against vesicular stomatitis virus in horses from southern, midwestern and northeastern Brazilian states
Original language	Portuguese
Pages (from-to)	1424-1429
Number of pages	6
Journal	Ciencia Rural
Volume	46
Issue number	8
DOIs	https://doi.org/10.1590/0103-8478cr20151135
State	Published - Aug 2016

Bibliographical note

Funding Information:
This reserach was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). LUNKES, V.L. (131011/2014-6), FLORES,E.F. and WEIBLEN, R. are recipients of Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) fellowships.

Publisher Copyright:
© 2016, Universidade Federal de Santa Maria. All Rights Reserved.

Keywords

Differential diagnosis
Foot-and-mouth disease
Serology
Vesicular disease
Zoonosis

Access

10.1590/0103-8478cr20151135

OpenUrl availability

Full text

Cite this

Lunkes, V. L., Tonin, A. A., Machado, G., Corbellini, L. G., Diehl, G. N., Santos, L. C. D., Bezerra, C. D. S., Azevedo, S. S. D., Pequeno, N. F., Silva, A. M. D., Weiblen, R., & Flores, E. F. (2016). Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil. Ciencia Rural, 46(8), 1424-1429. https://doi.org/10.1590/0103-8478cr20151135

Lunkes, VL, Tonin, AA, Machado, G, Corbellini, LG, Diehl, GN, Santos, LCD, Bezerra, CDS, Azevedo, SSD, Pequeno, NF, Silva, AMD, Weiblen, R & Flores, EF 2016, 'Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil', Ciencia Rural, vol. 46, no. 8, pp. 1424-1429. https://doi.org/10.1590/0103-8478cr20151135

@article{d26176273a324e52a09d6a059bcd7ef2,

title = "Anticorpos contra o v{\'i}rus da estomatite vesicular em equinos de Estados das regi{\~o}es sul, centro-oeste e nordeste do Brasil",

abstract = "Vesicular stomatitis virus (VSV) is the agent of a vesicular disease that affects many animal species and may be clinically confounded with foot-and-mouth disease in ruminant and swine. Horses are especially susceptible to VSV and may serve as sentinels for virus circulation. The present study investigated the presence of neutralizing antibodies against VSV Indiana III (VSIV-3) in serum samples of 3,626 horses from six states in three Brazilian regions: Southern (RS, n = 1,011), Midwest (GO/DF, n = 1,767) and Northeast (PB, PE, RN and CE, n = 848) collected between 2013 and 2014. Neutralizing antibodies against VSIV-3 (titers ≥40) were detected in 641 samples (positivity of 17.7%; CI95%:16.5-19.0%), being 317 samples from CE (87.3%; CI95%: 83.4-90.5%); 109 from RN (65.7%; CI95%: 57.8 -72.7%); 124 from PB (45.4%; CI95%: 39.4-51.5%); 78 from GO/DF (4.4%; CI95%: 3.5-5.5%) and nine samples of RS (0.9%; CI95%: 0.4-1.7%). Several samples from the Northeast and Midwest harbored high neutralizing titers, indicating a recent exposure to the virus. In contrast, samples from RS had low titers, possibly due to a past remote exposure. Several positive samples presented neutralizing activity against other VSV serotypes (Indiana I and New Jersey), yet in lower titers, indicating the specificity of the response to VSIV-3. These results demonstrated a relatively recent circulation of VSIV-3 in northeastern Brazilian States, confirming clinical findings and demonstrating the sanitary importance of this infection.",

keywords = "Differential diagnosis, Foot-and-mouth disease, Serology, Vesicular disease, Zoonosis",

author = "Lunkes, {Vin{\'i}cius Leobet} and Tonin, {Alexandre Alberto} and Gustavo Machado and Corbellini, {Luis Gustavo} and Diehl, {Gustavo Nogueira} and Santos, {Lucila Carboneiro dos} and Bezerra, {Camila de Sousa} and Azevedo, {S{\'e}rgio Santos de} and Pequeno, {Nebson Fernandes} and Silva, {Adriana Moraes da} and Rudi Weiblen and Flores, {Eduardo Furtado}",

note = "Funding Information: This reserach was supported by Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq). LUNKES, V.L. (131011/2014-6), FLORES,E.F. and WEIBLEN, R. are recipients of Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq) fellowships. Publisher Copyright: {\textcopyright} 2016, Universidade Federal de Santa Maria. All Rights Reserved.",

year = "2016",

month = aug,

doi = "10.1590/0103-8478cr20151135",

language = "Portuguese",

volume = "46",

pages = "1424--1429",

journal = "Ciencia Rural",

issn = "0103-8478",

publisher = "Universidade Federal de Santa Maria",

number = "8",

}

TY - JOUR

T1 - Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil

AU - Lunkes, Vinícius Leobet

AU - Tonin, Alexandre Alberto

AU - Machado, Gustavo

AU - Corbellini, Luis Gustavo

AU - Diehl, Gustavo Nogueira

AU - Santos, Lucila Carboneiro dos

AU - Bezerra, Camila de Sousa

AU - Azevedo, Sérgio Santos de

AU - Pequeno, Nebson Fernandes

AU - Silva, Adriana Moraes da

AU - Weiblen, Rudi

AU - Flores, Eduardo Furtado

N1 - Funding Information: This reserach was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). LUNKES, V.L. (131011/2014-6), FLORES,E.F. and WEIBLEN, R. are recipients of Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) fellowships. Publisher Copyright: © 2016, Universidade Federal de Santa Maria. All Rights Reserved.

PY - 2016/8

Y1 - 2016/8

N2 - Vesicular stomatitis virus (VSV) is the agent of a vesicular disease that affects many animal species and may be clinically confounded with foot-and-mouth disease in ruminant and swine. Horses are especially susceptible to VSV and may serve as sentinels for virus circulation. The present study investigated the presence of neutralizing antibodies against VSV Indiana III (VSIV-3) in serum samples of 3,626 horses from six states in three Brazilian regions: Southern (RS, n = 1,011), Midwest (GO/DF, n = 1,767) and Northeast (PB, PE, RN and CE, n = 848) collected between 2013 and 2014. Neutralizing antibodies against VSIV-3 (titers ≥40) were detected in 641 samples (positivity of 17.7%; CI95%:16.5-19.0%), being 317 samples from CE (87.3%; CI95%: 83.4-90.5%); 109 from RN (65.7%; CI95%: 57.8 -72.7%); 124 from PB (45.4%; CI95%: 39.4-51.5%); 78 from GO/DF (4.4%; CI95%: 3.5-5.5%) and nine samples of RS (0.9%; CI95%: 0.4-1.7%). Several samples from the Northeast and Midwest harbored high neutralizing titers, indicating a recent exposure to the virus. In contrast, samples from RS had low titers, possibly due to a past remote exposure. Several positive samples presented neutralizing activity against other VSV serotypes (Indiana I and New Jersey), yet in lower titers, indicating the specificity of the response to VSIV-3. These results demonstrated a relatively recent circulation of VSIV-3 in northeastern Brazilian States, confirming clinical findings and demonstrating the sanitary importance of this infection.

AB - Vesicular stomatitis virus (VSV) is the agent of a vesicular disease that affects many animal species and may be clinically confounded with foot-and-mouth disease in ruminant and swine. Horses are especially susceptible to VSV and may serve as sentinels for virus circulation. The present study investigated the presence of neutralizing antibodies against VSV Indiana III (VSIV-3) in serum samples of 3,626 horses from six states in three Brazilian regions: Southern (RS, n = 1,011), Midwest (GO/DF, n = 1,767) and Northeast (PB, PE, RN and CE, n = 848) collected between 2013 and 2014. Neutralizing antibodies against VSIV-3 (titers ≥40) were detected in 641 samples (positivity of 17.7%; CI95%:16.5-19.0%), being 317 samples from CE (87.3%; CI95%: 83.4-90.5%); 109 from RN (65.7%; CI95%: 57.8 -72.7%); 124 from PB (45.4%; CI95%: 39.4-51.5%); 78 from GO/DF (4.4%; CI95%: 3.5-5.5%) and nine samples of RS (0.9%; CI95%: 0.4-1.7%). Several samples from the Northeast and Midwest harbored high neutralizing titers, indicating a recent exposure to the virus. In contrast, samples from RS had low titers, possibly due to a past remote exposure. Several positive samples presented neutralizing activity against other VSV serotypes (Indiana I and New Jersey), yet in lower titers, indicating the specificity of the response to VSIV-3. These results demonstrated a relatively recent circulation of VSIV-3 in northeastern Brazilian States, confirming clinical findings and demonstrating the sanitary importance of this infection.

KW - Differential diagnosis

KW - Foot-and-mouth disease

KW - Serology

KW - Vesicular disease

KW - Zoonosis

UR - http://www.scopus.com/inward/record.url?scp=84974822728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974822728&partnerID=8YFLogxK

U2 - 10.1590/0103-8478cr20151135

DO - 10.1590/0103-8478cr20151135

M3 - Article

AN - SCOPUS:84974822728

SN - 0103-8478

VL - 46

SP - 1424

EP - 1429

JO - Ciencia Rural

JF - Ciencia Rural

IS - 8

ER -

Anticorpos contra o vírus da estomatite vesicular em equinos de Estados das regiões sul, centro-oeste e nordeste do Brasil

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this