Abstract
The structures of representative bicyclic peptides are confirmed through the NMR methods of HMBC and HMQC-TOCSY. Complete assignment of proton and carbon resonances is afforded by these two-dimensional NMR methods. HMQC-TOCSY is especially useful for assigning spectra in molecules having extensive proton spin systems and in establishing connectivities between protonated carbons. Long-range proton-carbon connectivities obtained by HMBC confirm structure in molecules containing heteroatoms or non-protonated carbons that interrupt proton spin systems.
Original language | English (US) |
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Pages (from-to) | 135-144 |
Number of pages | 10 |
Journal | Journal of Coordination Chemistry |
Volume | 32 |
Issue number | 1-3 |
DOIs | |
State | Published - Jun 1 1994 |
Externally published | Yes |
Keywords
- HMBC
- HMQC-TOCSY
- NMR
- bicyclic peptides