Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

Grace Lai; Karra Muller; Bob Carter; Clark Chen

doi:10.4103/2152-7806.159373

Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

Grace Lai, Karra Muller, Bob Carter, Clark Chen

Neurosurgery

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Abstract

Background: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. Case Description: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. Conclusion: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.

Original language	English (US)
Pages (from-to)	S295-S299
Journal	Surgical Neurology International
Volume	6
DOIs	https://doi.org/10.4103/2152-7806.159373
State	Published - Sep 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Lai G.

Keywords

Arteriovenous malformation
isocitrate dehydrogenase 1
oligodendroglioma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Carter, Bob

AU - Chen, Clark

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AB - Background: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. Case Description: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. Conclusion: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.

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KW - isocitrate dehydrogenase 1

KW - oligodendroglioma

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Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

Abstract

Bibliographical note

Keywords

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