Aryl sulfatase activities in normal and pathologic human articular cartilage

Edith R. Schwartz, Roy C. Ogle, Roby C. Thompson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Aryl sulfatase A and B activities were measured in articular cartilage of patients with osteoarthritis, chondromalacia, avascular necrosis, and femoral neck fractures. Although the activities of both enzymes were higher in the tissue from individuals with degenerative joint disease, the most significant finding was the substantial increase in the B:A ratio in these tissues. It is suggested that whereas cerebroside sulfate is the substrate for aryl sulfatase A, either chondroitin sulfate or keratan sulfate is the physiologic substrate for aryl sulfatase B.

Original languageEnglish (US)
Pages (from-to)455-467
Number of pages13
JournalArthritis & Rheumatism
Volume17
Issue number4
DOIs
StatePublished - 1974

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