TY - JOUR
T1 - Associations between depressive symptoms and inflammatory/hemostatic markers in women during the menopausal transition
AU - Matthews, Karen A.
AU - Schott, Laura L.
AU - Bromberger, Joyce
AU - Cyranowski, Jill
AU - Everson-Rose, Susan A.
AU - Sowers, Mary Fran
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: To test whether depressive symptoms are related to inflammatory and hemostatic markers in women approaching menopause. METHODS: A total of 3292 women enrolled in the Study of Women's Health Across the Nation (SWAN) were followed for five years and had measures of Center for Epidemiologic Studies-Depression and high sensitivity C-reactive protein, Factor VIIc, fibrinogen, plasminogen activator inhibitor Type 1(PAI-1), and tissue-type plasminogen activator antigen (tPA-ag) up to four times during the follow-up period. Women were pre- or early perimenopausal status at study entry and were of Caucasian, African American, Hispanic, Japanese, or Chinese race/ethnicity. RESULTS: Unadjusted longitudinal mixed regression models showed that over a 5-year period, higher depressive symptoms were related to higher fibrinogen, PAI-1, and tPA-ag levels, all p < .0001. Taking into account health history, medication use, ethnicity, aging, and menopausal status, the depressive symptoms were related to fibrinogen, p < .01, and PAI-1, p < .05. Depressive symptoms were related only to fibrinogen in models that also included body mass index, p < .05. CONCLUSIONS: Depressive symptoms may be associated with cardiovascular risk in perimenopausal women in part through hypercoagulability. This is the first study to test the association of depressive symptoms and hemostatic and inflammatory markers across time.
AB - OBJECTIVE: To test whether depressive symptoms are related to inflammatory and hemostatic markers in women approaching menopause. METHODS: A total of 3292 women enrolled in the Study of Women's Health Across the Nation (SWAN) were followed for five years and had measures of Center for Epidemiologic Studies-Depression and high sensitivity C-reactive protein, Factor VIIc, fibrinogen, plasminogen activator inhibitor Type 1(PAI-1), and tissue-type plasminogen activator antigen (tPA-ag) up to four times during the follow-up period. Women were pre- or early perimenopausal status at study entry and were of Caucasian, African American, Hispanic, Japanese, or Chinese race/ethnicity. RESULTS: Unadjusted longitudinal mixed regression models showed that over a 5-year period, higher depressive symptoms were related to higher fibrinogen, PAI-1, and tPA-ag levels, all p < .0001. Taking into account health history, medication use, ethnicity, aging, and menopausal status, the depressive symptoms were related to fibrinogen, p < .01, and PAI-1, p < .05. Depressive symptoms were related only to fibrinogen in models that also included body mass index, p < .05. CONCLUSIONS: Depressive symptoms may be associated with cardiovascular risk in perimenopausal women in part through hypercoagulability. This is the first study to test the association of depressive symptoms and hemostatic and inflammatory markers across time.
KW - Depression
KW - Hemostatis
KW - Inflammation
KW - Longitudinal
KW - Menopause
KW - Women
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U2 - 10.1097/01.psy.0000256574.30389.1b
DO - 10.1097/01.psy.0000256574.30389.1b
M3 - Article
C2 - 17289830
AN - SCOPUS:33847717881
SN - 0033-3174
VL - 69
SP - 124
EP - 130
JO - Psychosomatic medicine
JF - Psychosomatic medicine
IS - 2
ER -