Autism spectrum disorder screening with the CBCL/1½–5: Findings for young children at high risk for autism spectrum disorder

Leslie A. Rescorla, Breanna M. Winder-Patel, Sarah J. Paterson, Juhi Pandey, Jason J. Wolff, Robert T. Schultz, Joseph Piven

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The screening power of the CBCL/1½–5’s Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/1½–5’s Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (n2 p > 0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T ⩾ 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/1½–5’s Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed.

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalAutism
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2019

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The first author (L.A.R.) receives royalties from the University of Vermont Research Center for Children Youth, and Families, which publishes the CBCL/1½–5.

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by an NIH Autism Center of Excellence grant (NIMH and NICHD #HD055741 and HD055741-S1) to J.P.

Publisher Copyright:
© The Author(s) 2017.

Keywords

  • CBCL/1½–5
  • Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale
  • autism spectrum disorder screening
  • baby sibling paradigm
  • familial high-risk

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