Multiple characteristics of pretherapy Escherichia coli urine isolates from 39 children with acute, uncomplicated cystitis (including specific virulence genes and phylogenetic groups) identified an increased risk for recurrent bacteriuria after 3-day (but not 10-day) therapy with amoxicillin-clavulanate. Rapid testing conceivably could facilitate rational selection of treatment duration for pediatric cystitis. Certain traits might represent good targets for preventive interventions.
Bibliographical noteFunding Information:
Supported by Office of Research and Development, Medical Research Service, Department of Veterans Affairs (to J. R. J. and J. N. M.), and by grants from the National Institutes of Health (to J. R. J.).
- Escherichia coli infections
- Polymerase chain reaction
- Urinary tract infection