TY - JOUR
T1 - Bioenergetic consequences of left ventricular remodeling
AU - Zhang, Jianyi
AU - McDonald, Kenneth M.
PY - 1995/8/15
Y1 - 1995/8/15
N2 - Background: Left ventricular (LV) remodeling is associated with LV dysfunction and decrease of coronary flow reserve. The underlying mechanisms responsible for these alterations are unclear. Changes in myocardial high- energy phosphate levels may be associated with these alterations. Methods and Results: Twelve dogs with LV remodeling secondary to discrete necrosis produced by transmyocardial DC shock were compared with 8 normal dogs. LV mass and end-diastolic volume were measured by magnetic resonance imaging 7 days before and 12.9 ± 1.3 months after DC shock. Transmurally localized 31P nuclear magnetic resonance spectra from five layers across the LV wall were obtained simultaneously with transmural blood flow measurements (microspheres) under basal conditions and during pacing at 200 and 240 beats per minute. LV mass and end-diastolic volume were significantly increased after DC shock (33% and 26%, respectively, each P<.01). Under basal conditions, the subendocardial creatine phosphate (CP)/ATP ratio was significantly lower in remodeled LV compared with the control group (1.71 ± 0.09 versus 2.04 ± 0.09, P<.05). The subendocardial CP/ATP ratio was inversely correlated with both the increase in LV mass and LV end-diastolic volume (r=-.77 and r=-.70, P<.01 and P<.05, respectively). In remodeled myocardium, pacing induced a significant increase in LV end-diastolic pressure (from 8±1 to 20±3 mm Hg, P<.05), which was accompanied by a significant decrease of subendocardial/subepicardial (Endo/Epi) blood flow ratio (from 1.01±0.10 to 0.63±0.11, P<.05) and a significant decrease in subendocardial CP/ATP ratio (from 1.78±0.07 to 1.61 ± 0.10, P<.05) and increase of ΔPi/ATP ratio (from 0 to 0.24±0.05, P<.01). The decrease in subendocardial CP/ATP ratio was correlated with the decrease in Endo/Epi blood flow ratio (r=.79, P<.05). Conclusions: These results demonstrate that alterations in myocardial high-energy phosphate levels are correlated with the extent of LV remodeling. In remodeled hearts, pacing-induced tachycardia produces further changes of myocardial high-energy phosphate levels in the subendocardium that appear to be related to ventricular dysfunction and redistribution of blood flow away from the subendocardium.
AB - Background: Left ventricular (LV) remodeling is associated with LV dysfunction and decrease of coronary flow reserve. The underlying mechanisms responsible for these alterations are unclear. Changes in myocardial high- energy phosphate levels may be associated with these alterations. Methods and Results: Twelve dogs with LV remodeling secondary to discrete necrosis produced by transmyocardial DC shock were compared with 8 normal dogs. LV mass and end-diastolic volume were measured by magnetic resonance imaging 7 days before and 12.9 ± 1.3 months after DC shock. Transmurally localized 31P nuclear magnetic resonance spectra from five layers across the LV wall were obtained simultaneously with transmural blood flow measurements (microspheres) under basal conditions and during pacing at 200 and 240 beats per minute. LV mass and end-diastolic volume were significantly increased after DC shock (33% and 26%, respectively, each P<.01). Under basal conditions, the subendocardial creatine phosphate (CP)/ATP ratio was significantly lower in remodeled LV compared with the control group (1.71 ± 0.09 versus 2.04 ± 0.09, P<.05). The subendocardial CP/ATP ratio was inversely correlated with both the increase in LV mass and LV end-diastolic volume (r=-.77 and r=-.70, P<.01 and P<.05, respectively). In remodeled myocardium, pacing induced a significant increase in LV end-diastolic pressure (from 8±1 to 20±3 mm Hg, P<.05), which was accompanied by a significant decrease of subendocardial/subepicardial (Endo/Epi) blood flow ratio (from 1.01±0.10 to 0.63±0.11, P<.05) and a significant decrease in subendocardial CP/ATP ratio (from 1.78±0.07 to 1.61 ± 0.10, P<.05) and increase of ΔPi/ATP ratio (from 0 to 0.24±0.05, P<.01). The decrease in subendocardial CP/ATP ratio was correlated with the decrease in Endo/Epi blood flow ratio (r=.79, P<.05). Conclusions: These results demonstrate that alterations in myocardial high-energy phosphate levels are correlated with the extent of LV remodeling. In remodeled hearts, pacing-induced tachycardia produces further changes of myocardial high-energy phosphate levels in the subendocardium that appear to be related to ventricular dysfunction and redistribution of blood flow away from the subendocardium.
KW - hypertrophy
KW - ischemia
KW - myocardium
KW - phosphates
KW - spectroscopy
KW - ventricles
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U2 - 10.1161/01.CIR.92.4.1011
DO - 10.1161/01.CIR.92.4.1011
M3 - Article
C2 - 7641336
AN - SCOPUS:0029125732
SN - 0009-7322
VL - 92
SP - 1011
EP - 1019
JO - Circulation
JF - Circulation
IS - 4
ER -