TY - JOUR
T1 - Blood and Marrow Transplant Clinical Trials Network (BMT CTN)
T2 - Addressing Unanswered Questions
AU - Weisdorf, Daniel
AU - Carter, Shelly
AU - Confer, Dennis
AU - Ferrara, James
AU - Horowitz, Mary
PY - 2007/3
Y1 - 2007/3
N2 - Prospective clinical trials for blood transplantation and BMT are made more difficult by limited patient numbers, heterogeneity of clinical management strategies, and high-intensity therapy with frequent and toxic competing hazards. To address the challenges of prospective clinical study of BMT, the Blood and Marrow Transplant Clinical Trials Network (BMT CTN), sponsored by the National Heart, Lung, and Blood Institute/National Cancer Institute, was established. The network's charge is to design and execute multicenter clinical trials requiring participation from the network and from noncore centers for successful performance and to address rare diseases and unique populations that could not be well studied in individual centers. The BMT CTN organizational structure, current portfolio of studies, and scientific agenda are reviewed. Opportunities for investigators in any institution to propose trials and participate are outlined.
AB - Prospective clinical trials for blood transplantation and BMT are made more difficult by limited patient numbers, heterogeneity of clinical management strategies, and high-intensity therapy with frequent and toxic competing hazards. To address the challenges of prospective clinical study of BMT, the Blood and Marrow Transplant Clinical Trials Network (BMT CTN), sponsored by the National Heart, Lung, and Blood Institute/National Cancer Institute, was established. The network's charge is to design and execute multicenter clinical trials requiring participation from the network and from noncore centers for successful performance and to address rare diseases and unique populations that could not be well studied in individual centers. The BMT CTN organizational structure, current portfolio of studies, and scientific agenda are reviewed. Opportunities for investigators in any institution to propose trials and participate are outlined.
KW - Blood and marrow transplantation
KW - Clinical trials
UR - http://www.scopus.com/inward/record.url?scp=33847023872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847023872&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2006.11.017
DO - 10.1016/j.bbmt.2006.11.017
M3 - Editorial
C2 - 17317578
AN - SCOPUS:33847023872
SN - 1083-8791
VL - 13
SP - 257
EP - 262
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 3
ER -
