Body builder: from synthetic cells to engineered tissues

Shiqi Hu, Brenda M. Ogle, Ke Cheng

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

It is estimated that 18 Americans die every day waiting for an organ donation. And even if a patient receives the organ that s/he needs, there is still >10% chance that the new organ will not work. The field of tissue engineering and regenerative medicine aims to actively use a patient's own cells, plus biomaterials and factors, to grow specific tissues for replacement or to restore normal functions of that organ, which would eliminate the need for donors and the risk of alloimmune rejection. In this review, we summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering. At the end, we pointed to challenges and future directions for the field.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume54
DOIs
StatePublished - Oct 2018

Bibliographical note

Funding Information:
This work is supported by National Institute of Health grants HL123920 and HL137093 to KC and HL137204 and HL131017 to BMO.

Publisher Copyright:
© 2018

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