Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege; Lan Pham; Eric D. Jensen; Ann Emery; Tsang Hai Huang; Melissa Stemig; Hideyuki Beppu; Anna Petryk; Michael O'Connor; Kim Mansky; Raj Gopalakrishnan

doi:10.1074/jbc.M113.496950

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Aaron Broege, Lan Pham, Eric D. Jensen, Ann Emery, Tsang Hai Huang, Melissa Stemig, Hideyuki Beppu, Anna Petryk, Michael O'Connor, Kim Mansky, Raj Gopalakrishnan

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Abstract

Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

Original language	English (US)
Pages (from-to)	37230-37240
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.496950
State	Published - Dec 27 2013

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Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M., Mansky, K., & Gopalakrishnan, R. (2013). Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis. Journal of Biological Chemistry, 288(52), 37230-37240. https://doi.org/10.1074/jbc.M113.496950

Broege, A, Pham, L, Jensen, ED, Emery, A, Huang, TH, Stemig, M, Beppu, H, Petryk, A, O'Connor, M , Mansky, K & Gopalakrishnan, R 2013, 'Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis', Journal of Biological Chemistry, vol. 288, no. 52, pp. 37230-37240. https://doi.org/10.1074/jbc.M113.496950

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abstract = "Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.",

author = "Aaron Broege and Lan Pham and Jensen, {Eric D.} and Ann Emery and Huang, {Tsang Hai} and Melissa Stemig and Hideyuki Beppu and Anna Petryk and Michael O'Connor and Kim Mansky and Raj Gopalakrishnan",

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AU - Broege, Aaron

AU - Pham, Lan

AU - Jensen, Eric D.

AU - Emery, Ann

AU - Huang, Tsang Hai

AU - Stemig, Melissa

AU - Beppu, Hideyuki

AU - Petryk, Anna

AU - O'Connor, Michael

AU - Mansky, Kim

AU - Gopalakrishnan, Raj

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Y1 - 2013/12/27

N2 - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

AB - Background: BMPs affect osteoclastogenesis in vitro, but the effects of BMP signaling on osteoclastogenesis in vivo are not well understood. Results: Conditional deletion of BMPRII in osteoclasts results in reduced osteoclastogenesis, resulting in increased bone. Conclusion: BMP signaling is required for proper bone remodeling in vivo. Significance: Identifying factors affecting osteoclast differentiation increase understanding of bone remodeling regulation in vivo.

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Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

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