Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

Guang Wu Zhang; Dong Hua Zheng; Jing Nie; Teng Wang; Jun An Ma

doi:10.1039/b924272d

Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

Guang Wu Zhang, Dong Hua Zheng, Jing Nie, Teng Wang, Jun An Ma

Institute for Therapeutics Discovery and Development

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

Original language	English (US)
Pages (from-to)	1399-1405
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	6
DOIs	https://doi.org/10.1039/b924272d
State	Published - Mar 12 2010

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T1 - Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

AU - Zhang, Guang Wu

AU - Zheng, Dong Hua

AU - Nie, Jing

AU - Wang, Teng

AU - Ma, Jun An

PY - 2010/3/12

Y1 - 2010/3/12

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AB - A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

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JO - Organic and Biomolecular Chemistry

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ER -

Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

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