Brain Network Modularity During a Sustained Working-Memory Task

Marta Moraschi, Daniele Mascali, Silvia Tommasin, Tommaso Gili, Ibrahim Eid Hassan, Michela Fratini, Mauro DiNuzzo, Richard G. Wise, Silvia Mangia, Emiliano Macaluso, Federico Giove

Research output: Contribution to journalArticlepeer-review

Abstract

Spontaneous oscillations of the blood oxygenation level-dependent (BOLD) signal are spatially synchronized within specific brain networks and are thought to reflect synchronized brain activity. Networks are modulated by the performance of a task, even if the exact features and degree of such modulations are still elusive. The presence of networks showing anticorrelated fluctuations lend initially to suppose that a competitive relationship between the default mode network (DMN) and task positive networks (TPNs) supports the efficiency of brain processing. However, more recent results indicate that cooperative and competitive dynamics between networks coexist during task performance. In this study, we used graph analysis to assess the functional relevance of the topological reorganization of brain networks ensuing the execution of a steady state working-memory (WM) task. Our results indicate that the performance of an auditory WM task is associated with a switching between different topological configurations of several regions of specific networks, including frontoparietal, ventral attention, and dorsal attention areas, suggesting segregation of ventral attention regions in the presence of increased overall integration. However, the correct execution of the task requires integration between components belonging to all the involved networks.

Original languageEnglish (US)
Article number422
JournalFrontiers in Physiology
Volume11
DOIs
StatePublished - May 8 2020

Bibliographical note

Funding Information:
Funding. This work was partially supported by the Italian Ministry of Health, with the Young Researcher Grant 2013 (GR-2013-02358177, to MF) and with Ricerca Corrente (MM, DM, TG, and FG).

Funding Information:
This work was partially supported by the Italian Ministry of Health, with the Young Researcher Grant 2013 (GR-2013-02358177, to MF) and with Ricerca Corrente (MM, DM, TG, and FG).

Publisher Copyright:
© Copyright © 2020 Moraschi, Mascali, Tommasin, Gili, Hassan, Fratini, DiNuzzo, Wise, Mangia, Macaluso and Giove.

Keywords

  • brain segregation
  • connectivity dynamics
  • functional connectivity
  • modularity
  • topology
  • working memory

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