Breast cancer-related preferences among women with and without BRCA mutations

Victor R. Grann, Priya Patel, Anubha Bharthuar, Judith S. Jacobson, Ellen Warner, Kristin Anderson, Eiran Warner, Wei Yann Tsai, Kimberly A. Hill, Alfred I. Neugut, Dawn Hershman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Preference ratings are used to quantify quality of life in analyses used for health care policymaking. Subjects indicated how many years of their life expectancy they would trade to avoid BRCA mutations, breast/ovarian cancer, and five preventive measures including prophylactic surgery, annual mammograms, and annual magnetic resonance imaging (MRI). Among 243 respondents, both the 83 women with mutations and the 160 controls rated mammography highest (most favorably), MRI next highest, having a child with a mutation lowest, and ovarian cancer next lowest. Controls rated prophylactic surgery higher than cancer (P < 0.01), but women with mutations did not. In logistic regression, controls were twice as willing as women with mutations to trade time except for screening modalities; younger, lower-income, and non-white women were more willing to trade time than older, higher-income, and white women. Our findings support the use of average-risk individuals' time trade-off preference ratings for health care policy development.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalBreast Cancer Research and Treatment
Volume119
Issue number1
DOIs
StatePublished - Jan 2010

Bibliographical note

Funding Information:
Acknowledgments Supported in part by grant no. CRTG-98-260-01 from the American Cancer Society, Atlanta, GA (Spin Odyssey), and the Avon Breast Cancer Research and Care Program, and the Women-at-Risk Program

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • BRCA1/2 mutations
  • Cost-effectiveness
  • MRI and prophylactic surgery
  • Preferences
  • Quality-adjusted life years

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