TY - JOUR
T1 - Breast cancer-related preferences among women with and without BRCA mutations
AU - Grann, Victor R.
AU - Patel, Priya
AU - Bharthuar, Anubha
AU - Jacobson, Judith S.
AU - Warner, Ellen
AU - Anderson, Kristin
AU - Warner, Eiran
AU - Tsai, Wei Yann
AU - Hill, Kimberly A.
AU - Neugut, Alfred I.
AU - Hershman, Dawn
PY - 2010/1
Y1 - 2010/1
N2 - Preference ratings are used to quantify quality of life in analyses used for health care policymaking. Subjects indicated how many years of their life expectancy they would trade to avoid BRCA mutations, breast/ovarian cancer, and five preventive measures including prophylactic surgery, annual mammograms, and annual magnetic resonance imaging (MRI). Among 243 respondents, both the 83 women with mutations and the 160 controls rated mammography highest (most favorably), MRI next highest, having a child with a mutation lowest, and ovarian cancer next lowest. Controls rated prophylactic surgery higher than cancer (P < 0.01), but women with mutations did not. In logistic regression, controls were twice as willing as women with mutations to trade time except for screening modalities; younger, lower-income, and non-white women were more willing to trade time than older, higher-income, and white women. Our findings support the use of average-risk individuals' time trade-off preference ratings for health care policy development.
AB - Preference ratings are used to quantify quality of life in analyses used for health care policymaking. Subjects indicated how many years of their life expectancy they would trade to avoid BRCA mutations, breast/ovarian cancer, and five preventive measures including prophylactic surgery, annual mammograms, and annual magnetic resonance imaging (MRI). Among 243 respondents, both the 83 women with mutations and the 160 controls rated mammography highest (most favorably), MRI next highest, having a child with a mutation lowest, and ovarian cancer next lowest. Controls rated prophylactic surgery higher than cancer (P < 0.01), but women with mutations did not. In logistic regression, controls were twice as willing as women with mutations to trade time except for screening modalities; younger, lower-income, and non-white women were more willing to trade time than older, higher-income, and white women. Our findings support the use of average-risk individuals' time trade-off preference ratings for health care policy development.
KW - BRCA1/2 mutations
KW - Cost-effectiveness
KW - MRI and prophylactic surgery
KW - Preferences
KW - Quality-adjusted life years
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U2 - 10.1007/s10549-009-0373-6
DO - 10.1007/s10549-009-0373-6
M3 - Article
C2 - 19322653
AN - SCOPUS:72449128147
SN - 0167-6806
VL - 119
SP - 177
EP - 184
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -
