Bypass of DNA-protein cross-links conjugated to the 7-deazaguanine position of DNA by translesion synthesis polymerases

Medicine & Life Sciences

• 7-deazaguanine 100%
• link protein 64%
• DNA 26%
• Peptides 12%
• 2'-deoxycytidine 5'-triphosphate 11%
• Guanine 9%
• Amination 6%
• Mechlorethamine 5%
• DNA Primers 5%
• Aldehydes 4%
• DNA-Directed DNA Polymerase 4%
• Molecular Dynamics Simulation 4%
• Antineoplastic Agents 3%
• Catalytic Domain 3%
• Cisplatin 3%
• Nucleotides 3%
• Proteins 2%
• In Vitro Techniques 1%

Chemical Compounds

• dCTP 27%
• Peptide 27%
• Nitrogen Mustard 13%
• Reductive Amination 11%
• Cisplatin 10%
• Guanine 9%
• Antineoplastic Agent 8%
• Protein 7%
• Nucleotide 7%
• Molecular Dynamics 6%
• Adduct 6%
• Aldehyde 6%
• Simulation 5%
• Amount 4%