Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease

Terecita D. Yule, Mark B. Roth, Kimberly Dreier, Anthony F. Johnson, Melissa Palmer-Densmore, Kris Simmons, Robert Fanton

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Inflammatory changes following infection are central to the clinical manifestation of disease. However, information regarding such changes in animal disease is limited. In canine parvovirus infected puppies we measured the levels of acute phase proteins and changes in leukocyte phenotypes and cell trafficking by flow cytometry. These parameters correlated with conventional assessment of clinical disease in a vaccine efficacy study. Seropositive (CPV-2) 6-week-old puppies given three doses of a CPV-2 containing vaccine developed significant antibody titers and remained healthy after experimental infection with CPV-2b. Unvaccinated controls developed clinical signs and shed virus. Importantly, acute phase proteins became elevated, and lymphopenia, neutropenia and modulation of neutrophil-CD4 were detected in controls but not in vaccinates.

Original languageEnglish (US)
Pages (from-to)720-729
Number of pages10
JournalVaccine
Volume15
Issue number6-7
DOIs
StatePublished - Apr 1997

Keywords

  • CD4-neutrophil
  • acute phase proteins
  • canine parvovirus vaccine
  • leukopenia

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