Cardiac sodium channel mutations: Why so many phenotypes?

Medicine & Life Sciences

• Sodium Channels 100%
• Population Biological Variation 51%
• Phenotype 50%
• Mutation 47%
• Genetic Association Studies 45%
• Long QT syndrome type 3 37%
• Brugada Syndrome 29%
• Biophysics 28%
• Sick Sinus Syndrome 28%
• Gain of Function Mutation 27%
• Loss of Function Mutation 23%
• Dilated Cardiomyopathy 23%
• Body Temperature 21%
• Post Translational Protein Processing 21%
• Genetic Variation 20%
• Proteolysis 19%
• Atrial Fibrillation 18%
• Heart Diseases 17%
• RNA 14%
• Heart 13%
• Therapeutics 3%