Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery

Laura Hocum Stone, Tammy A. Butterick, Cayla Duffy, Corey Swingen, Herbert B. Ward, Rosemary F. Kelly, Edward O. McFalls

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (−14.7 ± 0.6 versus −14.8 ± 0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14 ± 0.36 and 5.05 ± 0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG.

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalJournal of cardiovascular translational research
Volume9
Issue number4
DOIs
StatePublished - Aug 1 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York (outside the USA).

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Bypass surgery
  • Chronically ischemic myocardium
  • Contractile reserve
  • Hibernating myocardium
  • MRI
  • Mitochondria
  • Oxidant stress

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