Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study

J. R B Musselman; Tracy L. Bergemann; Julie A. Ross; Charles Sklar; Kevin A.T. Silverstein; Erica K. Langer; Sharon A. Savage; Rajaram Nagarajan; Mark Krailo; David Malkin; Logan G. Spector

Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study

J. R B Musselman, Tracy L. Bergemann, Julie A. Ross, Charles Sklar, Kevin A.T. Silverstein, Erica K. Langer, Sharon A. Savage, Rajaram Nagarajan, Mark Krailo, David Malkin, Logan G. Spector

Research output: Book/Report › Commissioned report

Abstract

Osteosarcoma (OS) is a rare malignant bone tumor with an overall incidence rate of 4.6 cases per million children aged 0-19 years in the United States. While the etiology of OS is largely unknown, its distinctive age-incidence pattern suggests that growth and development is crucial in genesis. Prior studies have suggested that variants in genes in the estrogen metabolism (ESTR) and insulin-like growth factor/growth hormone (IGF/GH) pathways are associated with OS. We examined 798 single nucleotide polymorphisms (SNPs) in 42 genes from these pathways in a case-parent study (229 complete triads and 56 dyads) using buccal cell samples. Relative risks (RR) and 95% confidence intervals (CI) associated with transmitting one or two copies of the variant were estimated using log-linear models. After Bonferroni correction, 1 SNP within the ESTR pathway (rs1415270: RR = 0.50 and 8.37 for 1 and 2 vs. 0 copies, respectively; p = 0.010), and two SNPs in the IGF/GH pathway (rs1003737: RR = 0.91 and 0.0001 for 1 and 2 vs. 0 copies, respectively; p

Original language	English (US)
Volume	3
State	Published - 2012

Keywords

Osteosarcoma
Case-parent study
Estrogen metabolism pathway
Growth and development
Insulin-like growth factor pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

OpenUrl availability

Full text

Cite this

@book{2b10271deb604258b0406017e22c5b40,

title = "Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study",

abstract = "Osteosarcoma (OS) is a rare malignant bone tumor with an overall incidence rate of 4.6 cases per million children aged 0-19 years in the United States. While the etiology of OS is largely unknown, its distinctive age-incidence pattern suggests that growth and development is crucial in genesis. Prior studies have suggested that variants in genes in the estrogen metabolism (ESTR) and insulin-like growth factor/growth hormone (IGF/GH) pathways are associated with OS. We examined 798 single nucleotide polymorphisms (SNPs) in 42 genes from these pathways in a case-parent study (229 complete triads and 56 dyads) using buccal cell samples. Relative risks (RR) and 95% confidence intervals (CI) associated with transmitting one or two copies of the variant were estimated using log-linear models. After Bonferroni correction, 1 SNP within the ESTR pathway (rs1415270: RR = 0.50 and 8.37 for 1 and 2 vs. 0 copies, respectively; p = 0.010), and two SNPs in the IGF/GH pathway (rs1003737: RR = 0.91 and 0.0001 for 1 and 2 vs. 0 copies, respectively; p ",

keywords = "Osteosarcoma, Case-parent study, Estrogen metabolism pathway, Growth and development, Insulin-like growth factor pathway",

author = "Musselman, {J. R B} and Bergemann, {Tracy L.} and Ross, {Julie A.} and Charles Sklar and Silverstein, {Kevin A.T.} and Langer, {Erica K.} and Savage, {Sharon A.} and Rajaram Nagarajan and Mark Krailo and David Malkin and Spector, {Logan G.}",

year = "2012",

language = "English (US)",

volume = "3",

}

TY - BOOK

T1 - Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study

AU - Musselman, J. R B

AU - Bergemann, Tracy L.

AU - Ross, Julie A.

AU - Sklar, Charles

AU - Silverstein, Kevin A.T.

AU - Langer, Erica K.

AU - Savage, Sharon A.

AU - Nagarajan, Rajaram

AU - Krailo, Mark

AU - Malkin, David

AU - Spector, Logan G.

PY - 2012

Y1 - 2012

N2 - Osteosarcoma (OS) is a rare malignant bone tumor with an overall incidence rate of 4.6 cases per million children aged 0-19 years in the United States. While the etiology of OS is largely unknown, its distinctive age-incidence pattern suggests that growth and development is crucial in genesis. Prior studies have suggested that variants in genes in the estrogen metabolism (ESTR) and insulin-like growth factor/growth hormone (IGF/GH) pathways are associated with OS. We examined 798 single nucleotide polymorphisms (SNPs) in 42 genes from these pathways in a case-parent study (229 complete triads and 56 dyads) using buccal cell samples. Relative risks (RR) and 95% confidence intervals (CI) associated with transmitting one or two copies of the variant were estimated using log-linear models. After Bonferroni correction, 1 SNP within the ESTR pathway (rs1415270: RR = 0.50 and 8.37 for 1 and 2 vs. 0 copies, respectively; p = 0.010), and two SNPs in the IGF/GH pathway (rs1003737: RR = 0.91 and 0.0001 for 1 and 2 vs. 0 copies, respectively; p

AB - Osteosarcoma (OS) is a rare malignant bone tumor with an overall incidence rate of 4.6 cases per million children aged 0-19 years in the United States. While the etiology of OS is largely unknown, its distinctive age-incidence pattern suggests that growth and development is crucial in genesis. Prior studies have suggested that variants in genes in the estrogen metabolism (ESTR) and insulin-like growth factor/growth hormone (IGF/GH) pathways are associated with OS. We examined 798 single nucleotide polymorphisms (SNPs) in 42 genes from these pathways in a case-parent study (229 complete triads and 56 dyads) using buccal cell samples. Relative risks (RR) and 95% confidence intervals (CI) associated with transmitting one or two copies of the variant were estimated using log-linear models. After Bonferroni correction, 1 SNP within the ESTR pathway (rs1415270: RR = 0.50 and 8.37 for 1 and 2 vs. 0 copies, respectively; p = 0.010), and two SNPs in the IGF/GH pathway (rs1003737: RR = 0.91 and 0.0001 for 1 and 2 vs. 0 copies, respectively; p

KW - Osteosarcoma

KW - Case-parent study

KW - Estrogen metabolism pathway

KW - Growth and development

KW - Insulin-like growth factor pathway

M3 - Commissioned report

VL - 3

BT - Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study

ER -

Case-parent analysis of variation in pubertal hormone genes and pediatric osteosarcoma: A children's oncology group (COG) study

Abstract

Keywords

UN SDGs

OpenUrl availability

Fingerprint

Cite this