Castration increases [125I]MK801 binding in the hippocampus of male rats

Laura Kus; Robert J. Handa; Joan M. Hautman; Alvin J. Beitz

doi:10.1016/0006-8993(95)00384-3

Castration increases [¹²⁵I]MK801 binding in the hippocampus of male rats

Laura Kus, Robert J. Handa, Joan M. Hautman, Alvin J. Beitz

Research output: Contribution to journal › Article › peer-review

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Abstract

This study examines the effect of castration and androgen replacement on [¹²⁵I]MK801 binding in the hippocampus. In castrated male rats, [¹²⁵I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [¹²⁵I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [¹²⁵I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [¹²⁵I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.

Original language	English (US)
Pages (from-to)	270-274
Number of pages	5
Journal	Brain Research
Volume	683
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(95)00384-3
State	Published - Jun 19 1995

Bibliographical note

Funding Information:
This work was supported by NIH grants DA06682 and NS 31318 to A.J.B. and NSF-BNS9109226 to R.J.H. We thank Jennifer J. Sanderson for her excellent technical assistance.

Keywords

Androgen
Autoradiography
CA1
Castration
Hippocampus
MK801
N-Methyl-d-aspartate
Testosterone

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title = "Castration increases [125I]MK801 binding in the hippocampus of male rats",

abstract = "This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.",

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author = "Laura Kus and Handa, {Robert J.} and Hautman, {Joan M.} and Beitz, {Alvin J.}",

note = "Funding Information: This work was supported by NIH grants DA06682 and NS 31318 to A.J.B. and NSF-BNS9109226 to R.J.H. We thank Jennifer J. Sanderson for her excellent technical assistance.",

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AU - Beitz, Alvin J.

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