CD4+ lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes

Maxim C Cheeran; Genya Gekker; Shuxian Hu; Stephanie L. Yager; Phillip K. Peterson; James R Lokensgard

doi:10.1128/CDLI.7.4.710-713.2000

CD4⁺ lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes

Maxim C Cheeran, Genya Gekker, Shuxian Hu, Stephanie L. Yager, Phillip K. Peterson, James R Lokensgard

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Abstract

Cytomegalovirus-stimulated CD4⁺ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4⁺ lymphocytes play a role in defense of the brain against cytomegalovirus.

Original language	English (US)
Pages (from-to)	710-713
Number of pages	4
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1128/CDLI.7.4.710-713.2000
State	Published - Jul 2000

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title = "CD4+ lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes",

abstract = "Cytomegalovirus-stimulated CD4+ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4+ lymphocytes play a role in defense of the brain against cytomegalovirus.",

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AU - Cheeran, Maxim C

AU - Gekker, Genya

AU - Hu, Shuxian

AU - Yager, Stephanie L.

AU - Peterson, Phillip K.

AU - Lokensgard, James R

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AB - Cytomegalovirus-stimulated CD4+ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4+ lymphocytes play a role in defense of the brain against cytomegalovirus.

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CD4⁺ lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes

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