CD4+ lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes

Maxim C Cheeran, Genya Gekker, Shuxian Hu, Stephanie L. Yager, Phillip K. Peterson, James R Lokensgard

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cytomegalovirus-stimulated CD4+ lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4+ lymphocytes play a role in defense of the brain against cytomegalovirus.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume7
Issue number4
DOIs
StatePublished - Jul 2000

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