Central effects of neuropeptides on ventilation in the rat

Dennis E. Niewoehner, Allen S. Levine, John E. Morley

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We have examined the effects of centrally applied neuropeptides on ventilation (respiratory rate, tidal volume, and minute ventilation) in urethane-anesthetized rats. TRH caused an increase in respiratory rate, a decrease in tidal volume, but an increase in net minute ventilation. One TRH metabolite, acid TRH, caused similar changes, but no effect was observed from the other TRH metabolite, cHis-Pro. Both bombesin and calcitonin caused increases in minute ventilation due to increases in respiratory rate and tidal volume. Additionally, bombesin induced periodic sighing respirations at rates up to 15/minute which was observed with no other neuropeptide. Substance P, somatostatin, and neurotensin had no effect upon ventilation variables.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalPeptides
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1983

Keywords

  • Bombesin
  • Calcitonin
  • Neurotensin
  • Somatostatin
  • Substance P
  • TRH
  • Ventilation

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