Central effects of neuropeptides on ventilation in the rat

Dennis E. Niewoehner, Allen S. Levine, John E. Morley

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We have examined the effects of centrally applied neuropeptides on ventilation (respiratory rate, tidal volume, and minute ventilation) in urethane-anesthetized rats. TRH caused an increase in respiratory rate, a decrease in tidal volume, but an increase in net minute ventilation. One TRH metabolite, acid TRH, caused similar changes, but no effect was observed from the other TRH metabolite, cHis-Pro. Both bombesin and calcitonin caused increases in minute ventilation due to increases in respiratory rate and tidal volume. Additionally, bombesin induced periodic sighing respirations at rates up to 15/minute which was observed with no other neuropeptide. Substance P, somatostatin, and neurotensin had no effect upon ventilation variables.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalPeptides
Volume4
Issue number3
DOIs
StatePublished - 1983

Bibliographical note

Funding Information:
The peptides were obtained commercially: bombesin (0.1-10.0 /xg ICV: Sigma Chemical Company, St. Louis, MO); neurotensin (10/xg ICV: Vega Chemicals, Reno, NV); thyrotropin releasing hormone (TRH 0.1-10.0 /xg ICV: Boehringer-Mannheim, Indianapolis, IN); somatostatin (10 /xg ICV: Beckman, Palo Alto, CA); pyro-glutamyl histidyl proline (acid TRH 1.0-10.0 tzg ICV: Vega Biochemicals, Tuscon, AZ); substance P (10/zg ICV: Vega Biochemicals, Tucson, AZ); calcitonin (0.02-2.0 units ICV: Armour Pharmaceutical Company, Phoenix, AZ), histidyl-proline di-latopiperazine (cHis-Pro 10 /zg ICV: Vega Biochemicals Company, Tucson, AZ). All peptides were administered ICV in five microliters of physiological saline. Control animals ~This work was supported by the Veterans Administration Research Service. 2Requests for reprints should be addressed to John E. Morley, M.B., B. Ch., Minneapolis VA Medical Center, Minneapolis, MN 55417.

Keywords

  • Bombesin
  • Calcitonin
  • Neurotensin
  • Somatostatin
  • Substance P
  • TRH
  • Ventilation

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