Characterization of the solution degradation products of histrelin, a gonadotropin releasing hormone (LH/RH) agonist

Alan R. Oyler, Roxanne E. Naldi, John R. Lloyd, David A. Graden, Charles J. Shaw, Mary Lou Cotter

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The degradation products of histrelin (1, <Glu‐His‐Trp‐Ser‐Tyr‐(D‐Nim‐bzl‐His)‐Leu‐Arg‐Pro‐NHEt) were determined in aqueous solution at pH 5.4 and 87 °C over an 18‐day period (47% degradation). These degradation products (2–5) resulted from the cleavage of <Glu‐His and Trp‐Ser peptide bonds, His‐Trp diketopiperazine formation, and racemization of serine and histidine residues.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume80
Issue number3
DOIs
StatePublished - Mar 1991

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