Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen

Steven M.L. Neudorf; Tucker W. Lebien; John H. Kersey

doi:10.1016/0145-2126(84)90140-1

Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen

Steven M.L. Neudorf, Tucker W. Lebien, John H. Kersey

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Abstract

We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.

Original language	English (US)
Pages (from-to)	173-175,177-179
Journal	Leukemia research
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0145-2126(84)90140-1
State	Published - 1984

Keywords

Common acute lymphoblastic leukemia antigen
prothymocyte
terminal deoxynucleotidyl transferase

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title = "Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen",

abstract = "We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.",

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year = "1984",

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AU - Neudorf, Steven M.L.

AU - Lebien, Tucker W.

AU - Kersey, John H.

PY - 1984

Y1 - 1984

N2 - We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.

AB - We studied the relationship between CALLA + thymocytes and two known markers of T-lymphocyte differentiation, Tdt and the sheep erythrocyte receptor. Thymocytes were studied using double fluorochrome analysis (with monoclonal anti-CALLA antibody and anti-Tdt) before and after E rosette separation. We found that approx. 4% of unseparated thymocytes were CALLA + and that most CALLA + cells were also Tdt+. After E rosettes separation CALLA + Tdt + cells were found mostly in the ER- fraction (20% of ER- cells) while only 1.0% of ER + cells were CALLA +. The expression of CALLA on ER- Tdt + thymocytes suggests that CALLA may defined cells early in T-cell differentiation.

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KW - prothymocyte

KW - terminal deoxynucleotidyl transferase

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Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen

Abstract

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