Abstract
The capability of sensing catecholamine fluctuations in the brain is useful to determine how neurostimulation - both chemical and electrical - can affect catecholamine release and uptake. Here we report preliminary results on two multichannel neural probes capable of sensing dopamine through chronoamperometry methods. With a 16-channel microelectrode array and five-channel Michigan puffer probe with a microfluidic channel, we found that a 5-cycle dip coating process of Nafion, an ion-selective polymer, optimized sensitivity to dopamine and selectivity over ascorbic acid. In addition, through fluorescent microscopy, we have shown the suitability of Nafion as a "biocompatible" material for chronically implanted microelectrode probes. These findings support the ongoing work to develop chronic implantable chemical sensors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3333-3336 |
| Number of pages | 4 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 4 |
| State | Published - 2003 |
| Externally published | Yes |
| Event | A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico Duration: Sep 17 2003 → Sep 21 2003 |
Keywords
- Chemical detection
- Dopamine
- Drug delivery
- Nafion
- Neural interface