CHEMICAL STABILITY OF THIOPENTAL SODIUM INJECTION IN DISPOSABLE PLASTIC SYRINGES

V. Das Gupta; S. Neal Gardner; C. M. Jolowsky; D. R. Newcomer; K. R. Stewart

doi:10.1111/j.1365-2710.1987.tb00546.x

CHEMICAL STABILITY OF THIOPENTAL SODIUM INJECTION IN DISPOSABLE PLASTIC SYRINGES

V. Das Gupta, S. Neal Gardner, C. M. Jolowsky, D. R. Newcomer, K. R. Stewart

Pharmaceutical Care and Health Systems

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

The chemical stability of thiopental sodium injection (2.5%) when stored at 25° and 5° in disposable plastic syringes of two manufacturers (Monoject and Becton Dickenson and Co.) has been studied using the USP‐NF method. The injection appeared to be stable for five days at 25° and 45 days at 5° with a loss in potency of less than 7%. The thiopental sodium did not adsorb on the syringes. The pH values and the physical appearance did not change. An additional peak was obtained in the chromatogram from both the freshly prepared and the assay solution probably due to an impurity in the powder.

Original language	English (US)
Pages (from-to)	339-342
Number of pages	4
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	12
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2710.1987.tb00546.x
State	Published - Oct 1987

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abstract = "The chemical stability of thiopental sodium injection (2.5%) when stored at 25° and 5° in disposable plastic syringes of two manufacturers (Monoject and Becton Dickenson and Co.) has been studied using the USP‐NF method. The injection appeared to be stable for five days at 25° and 45 days at 5° with a loss in potency of less than 7%. The thiopental sodium did not adsorb on the syringes. The pH values and the physical appearance did not change. An additional peak was obtained in the chromatogram from both the freshly prepared and the assay solution probably due to an impurity in the powder.",

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AU - Stewart, K. R.

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AB - The chemical stability of thiopental sodium injection (2.5%) when stored at 25° and 5° in disposable plastic syringes of two manufacturers (Monoject and Becton Dickenson and Co.) has been studied using the USP‐NF method. The injection appeared to be stable for five days at 25° and 45 days at 5° with a loss in potency of less than 7%. The thiopental sodium did not adsorb on the syringes. The pH values and the physical appearance did not change. An additional peak was obtained in the chromatogram from both the freshly prepared and the assay solution probably due to an impurity in the powder.

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CHEMICAL STABILITY OF THIOPENTAL SODIUM INJECTION IN DISPOSABLE PLASTIC SYRINGES

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