TY - JOUR
T1 - Child maltreatment, adaptive functioning, and polygenic risk
T2 - A structural equation mixture model
AU - Thibodeau, Eric L.
AU - Masyn, Katherine E.
AU - Rogosch, Fred A.
AU - Cicchetti, Dante
N1 - Publisher Copyright:
© 2019 Cambridge University Press.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.
AB - This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.
UR - http://www.scopus.com/inward/record.url?scp=85062666223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062666223&partnerID=8YFLogxK
U2 - 10.1017/S0954579419000014
DO - 10.1017/S0954579419000014
M3 - Article
C2 - 30837010
AN - SCOPUS:85062666223
SN - 0954-5794
VL - 31
SP - 443
EP - 456
JO - Development and psychopathology
JF - Development and psychopathology
IS - 2
ER -