Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model

Eric L. Thibodeau, Katherine E. Masyn, Fred A. Rogosch, Dante Cicchetti

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.

Original languageEnglish (US)
Pages (from-to)443-456
Number of pages14
JournalDevelopment and psychopathology
Volume31
Issue number2
DOIs
StatePublished - May 1 2019

Bibliographical note

Funding Information:
The National Institute on Drug Abuse (R01DA17741), the National Institute of Mental Health (R01MH083979), the Jacobs Foundation, and the Spunk Fund, Inc., awarded to Dante Cicchetti supported this research. We wish to acknowledge Ann Masten, Gerald August, Kathleen Thomas, and William Oetting for critiquing the manuscript.

Publisher Copyright:
© 2019 Cambridge University Press.

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