Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model

Eric L. Thibodeau; Katherine E. Masyn; Fred A. Rogosch; Dante Cicchetti

doi:10.1017/S0954579419000014

Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model

Eric L. Thibodeau, Katherine E. Masyn, Fred A. Rogosch, Dante Cicchetti

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.

Original language	English (US)
Pages (from-to)	443-456
Number of pages	14
Journal	Development and psychopathology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1017/S0954579419000014
State	Published - May 1 2019

Bibliographical note

Funding Information:
The National Institute on Drug Abuse (R01DA17741), the National Institute of Mental Health (R01MH083979), the Jacobs Foundation, and the Spunk Fund, Inc., awarded to Dante Cicchetti supported this research. We wish to acknowledge Ann Masten, Gerald August, Kathleen Thomas, and William Oetting for critiquing the manuscript.

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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title = "Child maltreatment, adaptive functioning, and polygenic risk: A structural equation mixture model",

abstract = "This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.",

author = "Thibodeau, {Eric L.} and Masyn, {Katherine E.} and Rogosch, {Fred A.} and Dante Cicchetti",

note = "Funding Information: The National Institute on Drug Abuse (R01DA17741), the National Institute of Mental Health (R01MH083979), the Jacobs Foundation, and the Spunk Fund, Inc., awarded to Dante Cicchetti supported this research. We wish to acknowledge Ann Masten, Gerald August, Kathleen Thomas, and William Oetting for critiquing the manuscript.",

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doi = "10.1017/S0954579419000014",

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AU - Masyn, Katherine E.

AU - Rogosch, Fred A.

AU - Cicchetti, Dante

N1 - Funding Information: The National Institute on Drug Abuse (R01DA17741), the National Institute of Mental Health (R01MH083979), the Jacobs Foundation, and the Spunk Fund, Inc., awarded to Dante Cicchetti supported this research. We wish to acknowledge Ann Masten, Gerald August, Kathleen Thomas, and William Oetting for critiquing the manuscript.

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N2 - This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.

AB - This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing well-adjusted, externalizing, internalizing, and socially dominant groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.

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