Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study

Anna J. Podolanczuk; Ganesh Raghu; Michael Y. Tsai; Steven M. Kawut; Eric Peterson; Rajiv Sonti; Daniel Rabinowitz; Craig Johnson; R. Graham Barr; Karen Hinckley Stukovsky; Eric A. Hoffman; J. Jeffrey Carr; Firas S. Ahmed; David R. Jacobs; Karol Watson; Steven J. Shea; David J. Lederer

doi:10.1136/thoraxjnl-2016-209568

Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study

Anna J. Podolanczuk, Ganesh Raghu, Michael Y. Tsai, Steven M. Kawut, Eric Peterson, Rajiv Sonti, Daniel Rabinowitz, Craig Johnson, R. Graham Barr, Karen Hinckley Stukovsky, Eric A. Hoffman, J. Jeffrey Carr, Firas S. Ahmed, David R. Jacobs, Karol Watson, Steven J. Shea, David J. Lederer

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Abstract

We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between -600 and -250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45-84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.

Original language	English (US)
Pages (from-to)	472-474
Number of pages	3
Journal	Thorax
Volume	72
Issue number	5
DOIs	https://doi.org/10.1136/thoraxjnl-2016-209568
State	Published - Jan 27 2017

Bibliographical note

Funding Information:
The work is funded by the National Institutes of Health contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 and grants UL1-TR-000040, UL1-TR-001079, R01-HL-103676, RC1-HL100543, R01-HL-093081, R01-HL-077612, T32-HL-105323 and K24-HL-131937; by the Pulmonary Fibrosis Foundation; and by the Rocco Guinta Research Fund.

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Podolanczuk, A. J., Raghu, G., Tsai, M. Y., Kawut, S. M., Peterson, E., Sonti, R., Rabinowitz, D., Johnson, C., Barr, R. G., Stukovsky, K. H., Hoffman, E. A., Carr, J. J., Ahmed, F. S., Jacobs, D. R., Watson, K., Shea, S. J., & Lederer, D. J. (2017). Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study. Thorax, 72(5), 472-474. https://doi.org/10.1136/thoraxjnl-2016-209568

Podolanczuk, AJ, Raghu, G, Tsai, MY, Kawut, SM, Peterson, E, Sonti, R, Rabinowitz, D, Johnson, C, Barr, RG, Stukovsky, KH, Hoffman, EA, Carr, JJ, Ahmed, FS, Jacobs, DR, Watson, K, Shea, SJ & Lederer, DJ 2017, 'Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study', Thorax, vol. 72, no. 5, pp. 472-474. https://doi.org/10.1136/thoraxjnl-2016-209568

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title = "Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study",

abstract = "We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between -600 and -250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45-84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.",

author = "Podolanczuk, {Anna J.} and Ganesh Raghu and Tsai, {Michael Y.} and Kawut, {Steven M.} and Eric Peterson and Rajiv Sonti and Daniel Rabinowitz and Craig Johnson and Barr, {R. Graham} and Stukovsky, {Karen Hinckley} and Hoffman, {Eric A.} and Carr, {J. Jeffrey} and Ahmed, {Firas S.} and Jacobs, {David R.} and Karol Watson and Shea, {Steven J.} and Lederer, {David J.}",

note = "Funding Information: The work is funded by the National Institutes of Health contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 and grants UL1-TR-000040, UL1-TR-001079, R01-HL-103676, RC1-HL100543, R01-HL-093081, R01-HL-077612, T32-HL-105323 and K24-HL-131937; by the Pulmonary Fibrosis Foundation; and by the Rocco Guinta Research Fund.",

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AU - Peterson, Eric

AU - Sonti, Rajiv

AU - Rabinowitz, Daniel

AU - Johnson, Craig

AU - Barr, R. Graham

AU - Stukovsky, Karen Hinckley

AU - Hoffman, Eric A.

AU - Carr, J. Jeffrey

AU - Ahmed, Firas S.

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AU - Watson, Karol

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Cholesterol, lipoproteins and subclinical interstitial lung disease: The MESA study

Abstract

Bibliographical note

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