Abstract
An earlier demonstration of a circadian rhythm in rat atria by others is complemented herein by observations in culture: A single murine myocardial cell and two sets of grouped cells beating in culture for several days reveal several features of an anticipated, presumably built-in spectrum of multifrequency rhythms and trends, the chronome. Circadian and about 12-h (circasemidian) components are modulated by an approximately 84-h (circasemiseptan) component, which cannot be separated from trends in view of the brevity of the series. The circumstance under which the culture is aging and in which fibroblasts proliferate is a further complication that limits the findings to a single cycle reproduced in three separate cultures. Whether it is a rhythm that repeats itself or a response to placement into culture, an approximately 3.5-d component in the beating of myocardial cells in culture is to be aligned with a very prominent similar component found in the incidence of 85,819 human myocardial infarctions.
Original language | English (US) |
---|---|
Pages (from-to) | 217-229 |
Number of pages | 13 |
Journal | Cell Biophysics |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1991 |
Keywords
- Circadian
- caroliac myocyte
- chronobiology
- circasemidian
- circasemiseptan, chronome