TY - JOUR
T1 - Chronomics, human time estimation, and aging
AU - Halberg, Franz
AU - Sothern, Robert B.
AU - Cornelissen-Guillaume, Germaine G
AU - Czaplicki, Jerzy
PY - 2008
Y1 - 2008
N2 - Background: Circadian rhythm stage affects many outcomes, including those of mental aging. Methods: Estimations of 1 minute ∼ 5 times/day for a year, 25 years apart, by a healthy male biomedical scientist (RBS), are analyzed by the extended cosinor. Results: Cycles of a half-week, a week, ∼ 30 days, a half-year and a year, in self-assessed 1-minute estimation by RBS between 25 and 60 years of age in health, are mapped for the first time, compared and opposite effects are found. For RBS at 60 vs at 25 years of age, it takes less time in the morning around 10:30 (P < 0.001), but not in the evening around 19:30 (P = 0.956), to estimate 1 minute. Discussion: During the intervening decades, the time of estimating 1 minute differed greatly, dependent on circadian stage, being a linear decrease in the morning and increase in the evening, the latter modulated by a ∼ 33.6-year cycle. Conclusion: Circadian and infradian rhythm mapping is essential for a scrutiny of effects of aging. A ∼ 30-day and a circannual component apparent at 25 years of age are not found later; cycles longer than a year are detected. Rhythm stages await tests as markers for timing therapy in disease.
AB - Background: Circadian rhythm stage affects many outcomes, including those of mental aging. Methods: Estimations of 1 minute ∼ 5 times/day for a year, 25 years apart, by a healthy male biomedical scientist (RBS), are analyzed by the extended cosinor. Results: Cycles of a half-week, a week, ∼ 30 days, a half-year and a year, in self-assessed 1-minute estimation by RBS between 25 and 60 years of age in health, are mapped for the first time, compared and opposite effects are found. For RBS at 60 vs at 25 years of age, it takes less time in the morning around 10:30 (P < 0.001), but not in the evening around 19:30 (P = 0.956), to estimate 1 minute. Discussion: During the intervening decades, the time of estimating 1 minute differed greatly, dependent on circadian stage, being a linear decrease in the morning and increase in the evening, the latter modulated by a ∼ 33.6-year cycle. Conclusion: Circadian and infradian rhythm mapping is essential for a scrutiny of effects of aging. A ∼ 30-day and a circannual component apparent at 25 years of age are not found later; cycles longer than a year are detected. Rhythm stages await tests as markers for timing therapy in disease.
KW - Circadian rhythm
KW - Mental function
KW - Time estimation
UR - http://www.scopus.com/inward/record.url?scp=60749091569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60749091569&partnerID=8YFLogxK
M3 - Article
C2 - 19281067
AN - SCOPUS:60749091569
SN - 1176-9092
VL - 3
SP - 749
EP - 760
JO - Clinical interventions in aging
JF - Clinical interventions in aging
IS - 4
ER -