TY - JOUR
T1 - CNS involvement in the antisecretory action of [Met5]enkephalinamide on the rat intestine
AU - Brown, David R.
AU - Miller, Richard J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1983/6/17
Y1 - 1983/6/17
N2 - The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.
AB - The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.
KW - Antidiarrheal activity
KW - CNS site of action
KW - Cholera toxin
KW - Intestinal secretion
KW - [D-Ala,Met]enkephalinamide
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U2 - 10.1016/0014-2999(83)90569-1
DO - 10.1016/0014-2999(83)90569-1
M3 - Article
C2 - 6884432
AN - SCOPUS:0020571747
SN - 0014-2999
VL - 90
SP - 441
EP - 444
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 4
ER -
