Coexistent pulmonary and portal hypertension: Morphologic and clinical features

B. S. Edwards, E. K. Weir, W. D. Edwards, J. Ludwig, R. K. Dykoski, J. E. Edwards

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Patients with portal hypertension of varying etiology may develop pulmonary artery hypertension. In the present autopsy study, pulmonary and hepatic tissue was studied in 12 patients in whom pulmonary and portal hypertension coexisted. Plexogenic pulmonary arteriopathy was present in 10 patients, 7 of whom had coexistent thromboembolic lesions. One patient had isolated medial hypertrophy, which may be an early stage in the plexogenic category, whereas isolated thromboembolic pulmonary vascular disease was observed in one subject. Hepatic disease was consistent with alcoholic cirrhosis in seven patients, cryptogenic cirrhosis in four and extrahepatic portal hypertension without cirrhosis in one. Thrombocytopenia was present in all 10 patients whose platelet count was determined. This study suggests that pulmonary hypertension associated with portal hypertension commonly has a plexogenic appearance on histologic examination. However, thrombosis (whether embolic or in situ) may also contribute to vascular obstruction.

Original languageEnglish (US)
Pages (from-to)1233-1238
Number of pages6
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - 1987

Bibliographical note

Funding Information:
Pathology, diology and neapolis, Minnesota and the St. Paul and the University of supported by The Saint Paul Foundation, Minneapolis and The Mayo Foundation, Rochester. Dr. Brooks S. Edwards is supported by Institutes of Health, Bethesda, Manuscript received February June 29, 1987, accepted July 14, 1987.

Copyright 2017 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Coexistent pulmonary and portal hypertension: Morphologic and clinical features'. Together they form a unique fingerprint.

Cite this