Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia

Susan L. Slager; Christine F. Skibola; Maria Chiara Di Bernardo; Lucia Conde; Peter Broderick; Shannon K. McDonnell; Lynn R. Goldin; Naomi Croft; Amy Holroyd; Shelley Harris; Jacques Riby; Daniel J. Serie; Neil E. Kay; Timothy G. Call; Paige M. Bracci; Eran Halperin; Mark C. Lanasa; Julie M. Cunningham; Jose F. Leis; Vicki A. Morrison; Logan G. Spector; Celine M. Vachon; Tait D. Shanafelt; Sara S. Strom; Nicola J. Camp; J. Brice Weinberg; Estella Matutes; Neil E. Caporaso; Rachel Wade; Martin J S Dyer; Claire Dearden; James R. Cerhan; Daniel Catovsky; Richard S. Houlston

doi:10.1182/blood-2012-03-413591

Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia

Susan L. Slager, Christine F. Skibola, Maria Chiara Di Bernardo, Lucia Conde, Peter Broderick, Shannon K. McDonnell, Lynn R. Goldin, Naomi Croft, Amy Holroyd, Shelley Harris, Jacques Riby, Daniel J. Serie, Neil E. Kay, Timothy G. Call, Paige M. Bracci, Eran Halperin, Mark C. Lanasa, Julie M. Cunningham, Jose F. Leis, Vicki A. MorrisonLogan G. Spector, Celine M. Vachon, Tait D. Shanafelt, Sara S. Strom, Nicola J. Camp, J. Brice Weinberg, Estella Matutes, Neil E. Caporaso, Rachel Wade, Martin J S Dyer, Claire Dearden, James R. Cerhan, Daniel Catovsky, Richard S. Houlston

Pediatrics - Pediatric Epidemiology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We performed a meta-analysis of 3 genomewide association studies to identify additional common variants influencing chronic lymphocytic leukemia (CLL) risk. The discovery phase was composed of genome-wide association study data from 1121 cases and 3745 controls. Replication analysis was performed in 861 cases and 2033 controls. We identified a novel CLL risk locus at 6p21.33 (rs210142; intronic to the BAK1 gene, BCL2 antagonist killer 1; P = 9.47 × 10 ^-16). A strong relationship between risk genotype and reduced BAK1 expression was shown in lymphoblastoid cell lines. This finding provides additional support for polygenic inheritance to CLL and provides further insight into the biologic basis of disease development.

Original language	English (US)
Pages (from-to)	843-846
Number of pages	4
Journal	Blood
Volume	120
Issue number	4
DOIs	https://doi.org/10.1182/blood-2012-03-413591
State	Published - Jul 26 2012

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Slager, S. L., Skibola, C. F., Di Bernardo, M. C., Conde, L., Broderick, P., McDonnell, S. K., Goldin, L. R., Croft, N., Holroyd, A., Harris, S., Riby, J., Serie, D. J., Kay, N. E., Call, T. G., Bracci, P. M., Halperin, E., Lanasa, M. C., Cunningham, J. M., Leis, J. F., ... Houlston, R. S. (2012). Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Blood, 120(4), 843-846. https://doi.org/10.1182/blood-2012-03-413591

Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. / Slager, Susan L.; Skibola, Christine F.; Di Bernardo, Maria Chiara; Conde, Lucia; Broderick, Peter; McDonnell, Shannon K.; Goldin, Lynn R.; Croft, Naomi; Holroyd, Amy; Harris, Shelley; Riby, Jacques; Serie, Daniel J.; Kay, Neil E.; Call, Timothy G.; Bracci, Paige M.; Halperin, Eran; Lanasa, Mark C.; Cunningham, Julie M.; Leis, Jose F.; Morrison, Vicki A.; Spector, Logan G.; Vachon, Celine M.; Shanafelt, Tait D.; Strom, Sara S.; Camp, Nicola J.; Weinberg, J. Brice; Matutes, Estella; Caporaso, Neil E.; Wade, Rachel; Dyer, Martin J S; Dearden, Claire; Cerhan, James R.; Catovsky, Daniel; Houlston, Richard S.

In: Blood, Vol. 120, No. 4, 26.07.2012, p. 843-846.

Research output: Contribution to journal › Article › peer-review

Slager, SL, Skibola, CF, Di Bernardo, MC, Conde, L, Broderick, P, McDonnell, SK, Goldin, LR, Croft, N, Holroyd, A, Harris, S, Riby, J, Serie, DJ, Kay, NE, Call, TG, Bracci, PM, Halperin, E, Lanasa, MC, Cunningham, JM, Leis, JF, Morrison, VA, Spector, LG, Vachon, CM, Shanafelt, TD, Strom, SS, Camp, NJ, Weinberg, JB, Matutes, E, Caporaso, NE, Wade, R, Dyer, MJS, Dearden, C, Cerhan, JR, Catovsky, D & Houlston, RS 2012, 'Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia', Blood, vol. 120, no. 4, pp. 843-846. https://doi.org/10.1182/blood-2012-03-413591

Slager, Susan L. ; Skibola, Christine F. ; Di Bernardo, Maria Chiara ; Conde, Lucia ; Broderick, Peter ; McDonnell, Shannon K. ; Goldin, Lynn R. ; Croft, Naomi ; Holroyd, Amy ; Harris, Shelley ; Riby, Jacques ; Serie, Daniel J. ; Kay, Neil E. ; Call, Timothy G. ; Bracci, Paige M. ; Halperin, Eran ; Lanasa, Mark C. ; Cunningham, Julie M. ; Leis, Jose F. ; Morrison, Vicki A. ; Spector, Logan G. ; Vachon, Celine M. ; Shanafelt, Tait D. ; Strom, Sara S. ; Camp, Nicola J. ; Weinberg, J. Brice ; Matutes, Estella ; Caporaso, Neil E. ; Wade, Rachel ; Dyer, Martin J S ; Dearden, Claire ; Cerhan, James R. ; Catovsky, Daniel ; Houlston, Richard S. / Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. In: Blood. 2012 ; Vol. 120, No. 4. pp. 843-846.

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abstract = "We performed a meta-analysis of 3 genomewide association studies to identify additional common variants influencing chronic lymphocytic leukemia (CLL) risk. The discovery phase was composed of genome-wide association study data from 1121 cases and 3745 controls. Replication analysis was performed in 861 cases and 2033 controls. We identified a novel CLL risk locus at 6p21.33 (rs210142; intronic to the BAK1 gene, BCL2 antagonist killer 1; P = 9.47 × 10 -16). A strong relationship between risk genotype and reduced BAK1 expression was shown in lymphoblastoid cell lines. This finding provides additional support for polygenic inheritance to CLL and provides further insight into the biologic basis of disease development.",

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AU - Broderick, Peter

AU - McDonnell, Shannon K.

AU - Goldin, Lynn R.

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AU - Riby, Jacques

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AU - Lanasa, Mark C.

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AU - Leis, Jose F.

AU - Morrison, Vicki A.

AU - Spector, Logan G.

AU - Vachon, Celine M.

AU - Shanafelt, Tait D.

AU - Strom, Sara S.

AU - Camp, Nicola J.

AU - Weinberg, J. Brice

AU - Matutes, Estella

AU - Caporaso, Neil E.

AU - Wade, Rachel

AU - Dyer, Martin J S

AU - Dearden, Claire

AU - Cerhan, James R.

AU - Catovsky, Daniel

AU - Houlston, Richard S.

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