Comparison of Endothelial Function in Asian Indians Versus Caucasians

Snigdha Pusalavidyasagar, Fatima H Sert Kuniyoshi, Abu S M Shamsuzzaman, Prachi Singh, Shantal Maharaj, Pavel Leinveber, Jiri Nykodym, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Asian Indians have markedly increased mortality due to coronary artery disease (CAD). Impaired endothelial function has been linked to an increased risk of acute cardiovascular events. We tested the hypothesis that endothelial function was attenuated in Asian Indians and Caucasians. Methods: We studied 14 Asian Indians [mean age: 30 ± 6 years; mean body mass index (BMI): 25 ± 3 kg/m2] and 11 Caucasians (mean age: 30 ± 5 years; mean BMI: 26 ± 2 kg/m2). All 25 subjects were healthy men and nonsmokers without any history of CAD or diabetes and were not taking medications. Endothelial function was evaluated by ultrasound measures of flow-mediated dilatation (FMD) and endothelium-independent nonflow mediated vasodilatation (NFMD) of the brachial artery, in the morning immediately after awakening (6 a.m.) in a fasting state. Results: Mean age, BMI, apnea-hypopnea index, heart rate, and blood pressure were similar in both groups (P = >0.05). When correcting for body surface area, brachial artery diameter was not different between the two groups (2.1% ± 0.3% vs. 2.2% ± 0.4%; P = 0.29). FMD and NFMD were similar in Asian Indians and Caucasians (5.9% ± 4.1% vs. 5.7% ± 2.6%, P = 0.70; 16.4% ± 8% vs. 14.8% ± 4.1%, P = 0.58, respectively). Conclusion: Endothelial function in Asian Indian men is not attenuated in comparison to Caucasian men.

Original languageEnglish (US)
Pages (from-to)363-367
Number of pages5
JournalMetabolic Syndrome and Related Disorders
Volume14
Issue number7
DOIs
StatePublished - Sep 1 2016

Bibliographical note

Funding Information:
This study was supported by NIH grant HL-65176 and also by UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2016, Mary Ann Liebert, Inc.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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