Comparison of high-frequency jet ventilation and conventional mechanical ventilation in a meconium aspiration model

Mark C. Mammel, Margaret J. Gordon, John E. Connett, Stephen J. Boros

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Ten adult cats received alternately high-frequency jet ventilation and conventional mechanical ventilation after aspirating 2 ml/kg 25% human meconium in saline. Equivalent mean airway pressures were maintained during the hourly ventilator changes. Aortic pressures, pulmonary artery pressures, and central venous pressures were continuously monitored. Cardiac outputs were measured, and pulmonary and systemic vascular resistances, intrapulmonary shunts, and alveolar arterial oxygen gradients were determined at regular intervals. During the first hour after aspiration, AaDO2 and Qs/Qt were lower during HFJV (P<0.05); PVR and Pa were always higher during HFJV (P<0.05). Overall, PVR, Pa, AaDO2 and Qs/Qt rose during HFJV; these changes occurred at equivalent Paw within 15 minutes of each ventilator change (P<0.05). In this meconium aspiration model, conventional mechanical ventilation was the superior form of ventilatory therapy.

Original languageEnglish (US)
Pages (from-to)630-634
Number of pages5
JournalThe Journal of pediatrics
Volume103
Issue number4
DOIs
StatePublished - Oct 1983

Bibliographical note

Funding Information:
From the Infant Pulmonary Research Center, Children's Hospital of St. Paul, and the Departments of PeekiOtrics and Biometry, University of Minnesota. Supported in part by grants from the 3M Foundation and the Research and Education Fund of St. Paul Children's Hospital. Reprint requests: Mark C. Mammel, M.D., Rm. 2100, Children's Hospital, 345 N. Smith Ave., St. Paul, MN 55102.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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