Constitutively active STAT5 constructs

Lynn M. Heltemes-Harris; Michael A. Farrar

doi:10.1007/978-1-62703-242-1_16

Constitutively active STAT5 constructs

Lynn M. Heltemes-Harris, Michael A. Farrar

Laboratory Medicine and Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The transcription factor S ignal T randucer and A ctivator of T ranscription 5 (STAT5) plays an important role in many biological processes. To study STAT5 biology, several different constructs have been designed that render STAT5 constitutively active. These constructs have now been used to generate animal models that allow for targeted expression of constitutively active STAT5 including a model where STAT5 is expressed in developing B and T cells. Herein we brie fly describe the design of constitutively active STAT5 constructs and recent advances in their use.

Original language	English (US)
Title of host publication	JAK-STAT Signalling
Subtitle of host publication	Methods and Protocols
Publisher	Humana Press Inc.
Pages	225-232
Number of pages	8
ISBN (Print)	9781627032414
DOIs	https://doi.org/10.1007/978-1-62703-242-1_16
State	Published - 2013

Publication series

Name	Methods in Molecular Biology
Volume	967
ISSN (Print)	1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2013.

Keywords

CD4
Constitutively active
Phospho flow
STAT5
Tregs

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Constitutively active STAT5 constructs

Abstract

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Keywords

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