Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog

Robert J Bache; F. R. Cobb; J. C. Greenfield

Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog

Robert J Bache, F. R. Cobb, J. C. Greenfield

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

Abstract

Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.

Original language	English (US)
Pages (from-to)	755-762
Number of pages	8
Journal	Cardiovascular Research
Volume	7
Issue number	6
State	Published - Dec 1 1973

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title = "Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog",

abstract = "Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.",

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AB - Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.

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Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog

Abstract

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