Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog

Robert J Bache, F. R. Cobb, J. C. Greenfield

Research output: Contribution to journalArticlepeer-review

Abstract

Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalCardiovascular Research
Volume7
Issue number6
StatePublished - Dec 1 1973

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