TY - JOUR
T1 - Coronary blood flow during exercise following nonselective and selective α1-adrenergic blockade with indoramin
AU - Dai, Xue Zheng
AU - Herzog, Charles A.
AU - Schwartz, Jeffrey S.
AU - Bache, Robert J.
PY - 1986/5
Y1 - 1986/5
N2 - Studies were performed to compare the effects of α1-adrenergic blockade with indoramin and nonselective α-adrenergic blockade with phentolamine on coronary blood flow and myocardial oxygen consumption during exercise. Nine dogs trained to run on a motor-driven treadmill were instrumented with electromagnetic flowmeter probes on the left circumflex coronary artery, and aortic and coronary sinus catheters for determination of myocardial arteriovenous oxygen difference. During control conditions, myocardial oxygen consumption and coronary blood flow increased as a direct function of heart rate during exercise. Phentolamine caused a significant decrease in blood pressure, while heart rate, coronary blood flow, and myocardial oxygen consumption were significantly increased at rest and during all exercise stages. Although α1-adrenergic blockade with indoramin caused a similar reduction of arterial pressure, heart rate was unaltered both at rest and during exercise. Coronary blood flow and myocardial oxygen consumption were unchanged by α1-adrenergic blockade at rest and during light exercise; however, during the heaviest exercise stages α1-blockade caused a significant decrease in myocardial oxygen consumption. These findings are in agreement with the concept that phentolamine, by blocking presynaptic α2-adrenoceptors which normaliy modulate norepinephrine release, increases sympathetic activity during exercise while indoramin, by acting as a selective α1-adrenergic blocker, does not produce this effect.
AB - Studies were performed to compare the effects of α1-adrenergic blockade with indoramin and nonselective α-adrenergic blockade with phentolamine on coronary blood flow and myocardial oxygen consumption during exercise. Nine dogs trained to run on a motor-driven treadmill were instrumented with electromagnetic flowmeter probes on the left circumflex coronary artery, and aortic and coronary sinus catheters for determination of myocardial arteriovenous oxygen difference. During control conditions, myocardial oxygen consumption and coronary blood flow increased as a direct function of heart rate during exercise. Phentolamine caused a significant decrease in blood pressure, while heart rate, coronary blood flow, and myocardial oxygen consumption were significantly increased at rest and during all exercise stages. Although α1-adrenergic blockade with indoramin caused a similar reduction of arterial pressure, heart rate was unaltered both at rest and during exercise. Coronary blood flow and myocardial oxygen consumption were unchanged by α1-adrenergic blockade at rest and during light exercise; however, during the heaviest exercise stages α1-blockade caused a significant decrease in myocardial oxygen consumption. These findings are in agreement with the concept that phentolamine, by blocking presynaptic α2-adrenoceptors which normaliy modulate norepinephrine release, increases sympathetic activity during exercise while indoramin, by acting as a selective α1-adrenergic blocker, does not produce this effect.
KW - Coronary sinus Po
KW - Indoramin
KW - Myocardial oxygen consumption
KW - Phentolamine
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U2 - 10.1097/00005344-198605000-00022
DO - 10.1097/00005344-198605000-00022
M3 - Article
C2 - 2425176
AN - SCOPUS:0022470957
SN - 0160-2446
VL - 8
SP - 574
EP - 581
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
IS - 3
ER -