Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

Abdolrahim Nikzamir, Manouchehr Nakhjavani, Alireza Esteghamati, Armin Rashidi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The activity of the renin-angiotensin-aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy. However, the effect of angiotensin-converting enzyme (ACE) inhibition on the RAAS appears to be modulated by a number of factors including the I/D polymorphism of the ACE genotype. In this study, we attempted to find independent correlates of ACE activity in 121 macroalbuminuric type 2 diabetic Iranian patients under chronic ACE inhibition. Both univariate and multivariate analyses were used. The presence of the D allele was independently associated with significantly higher levels of ACE activity (with the II genotype as reference, P < 0.001, B = 27.3, 95% CI = 17.6-37.1), and this association was not eliminated by potentially confounding variables. In conclusion, the D allele is a significant independent correlate of ACE activity in macroalbuminuric type 2 diabetic Iranian patients under long-term ACE inhibition.

Original languageEnglish (US)
Pages (from-to)1274-1277
Number of pages4
JournalNephrology Dialysis Transplantation
Volume23
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • ACE activity
  • Diabetic nephropathy
  • Macroalbuminuria
  • Polymorphism
  • Type 2 diabetes

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