TY - JOUR
T1 - Cortical bone microperfusion
T2 - Response to ischemia and changes in major arterial blood flow
AU - Swiontkowski, Marc F.
AU - Senft, David
PY - 1992/5
Y1 - 1992/5
N2 - In order to investigate the effects of short‐term ischemia on cortical bone microperfusion, an isolated porcine tibia diaphyseal preparation based on intact nutrient vessels was developed. Laser Doppler flowmetry (LDF) was utilized to assess continuously the cortical microcirculation and the response to short‐term ischemia. The femoral artery was isolated and clamped to develop the condition of bone ischemia. On release of the clamp, reactive hyperemia was documented in all animals. Using a roller pump connected to a segment of femoral artery, the same preparation was utilized to investigate the effect of a changing femoral artery flow on the cortical microcirculation. A positive correlation between LDF output and change in arterial inflow (r = 0.64) was defined. This model has the potential for studying the effect of ischemia on bone cell viability.
AB - In order to investigate the effects of short‐term ischemia on cortical bone microperfusion, an isolated porcine tibia diaphyseal preparation based on intact nutrient vessels was developed. Laser Doppler flowmetry (LDF) was utilized to assess continuously the cortical microcirculation and the response to short‐term ischemia. The femoral artery was isolated and clamped to develop the condition of bone ischemia. On release of the clamp, reactive hyperemia was documented in all animals. Using a roller pump connected to a segment of femoral artery, the same preparation was utilized to investigate the effect of a changing femoral artery flow on the cortical microcirculation. A positive correlation between LDF output and change in arterial inflow (r = 0.64) was defined. This model has the potential for studying the effect of ischemia on bone cell viability.
KW - Bone blood flow
KW - Ischemia
KW - Laser Doppler flowmetry
KW - Microperfusion
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U2 - 10.1002/jor.1100100305
DO - 10.1002/jor.1100100305
M3 - Article
C2 - 1569496
AN - SCOPUS:0026864065
SN - 0736-0266
VL - 10
SP - 337
EP - 343
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
IS - 3
ER -