Creation of reversible cholestatic rat model

Gokulakkrishna Subhas, Jasneet Bhullar, Vijay K. Mittal, Michael J. Jacobs

Research output: Contribution to journalArticlepeer-review


Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Cholestasis can cause various physiological changes and affect the nutritional status and surgical outcomes. Study of the pathophysiological changes occurring in the liver and other organs is of importance. Various studies have been done in cholestatic rat models.We used a reversible cholestatic rat model in our recent study looking at the role of methylprednisolone in the ischemia reperfusion injury. Various techniques for creation of a reversible cholestatic model have been described. Creation of a reversible cholestatic rat model can be challenging in view of the smaller size and unique hepatopancreatobiliary anatomy in rats. This video article demonstrates the creation of a reversible cholestatic model.This model can be used in various studies, such as looking at the changes in nutritional, physiological, pathological, histological and immunological changes in the gastrointestinal tract. This model can also be used to see the effects of cholestasis and various therapeutic interventions on major hepatic surgeries.

Original languageEnglish (US)
Article numbere2692
JournalJournal of Visualized Experiments
Issue number51
StatePublished - May 2011


  • Bile duct obstruction
  • Choledochoduodenostomy
  • Cholestasis
  • Issue 51
  • Medicine
  • Rat model
  • Reversible cholestasis


Dive into the research topics of 'Creation of reversible cholestatic rat model'. Together they form a unique fingerprint.

Cite this