CRH challenge test in anxious depression

William H. Meller, Roger G. Kathol, Stephen D. Samuelson, Timothy L. Gehris, Brendon T. Carroll, Andrew F. Pitts, Paula J. Clayton

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.

Original languageEnglish (US)
Pages (from-to)376-382
Number of pages7
JournalBiological Psychiatry
Issue number6
StatePublished - Mar 15 1995


  • Corticotropin-releasing hormone
  • anxious depression


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