Abstract
CD4+ germinal center (GC)-T follicular helper (Tfh) cells help B cells become long-lived plasma cells and memory cells. The transcriptional repressor Bcl6 plays a key role in GC-Tfh formation by inhibiting the expression of genes that promote differentiation into other lineages. We determined whether BCOR, a component of a Polycomb repressive complex that interacts with the Bcl6 BTB domain, influences GC-Tfh differentiation. T cell-targeted BCOR deficiency led to a substantial loss of peptide:MHC class II-specific GC-Tfh cells following Listeria monocytogenes infection and a 2-fold decrease following immunization with a peptide in CFA. The reduction in GC-Tfh cells was associated with diminished plasma cell and GC B cell formation. Thus, T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
Original language | English (US) |
---|---|
Pages (from-to) | 5604-5608 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 194 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2015 |
Bibliographical note
Publisher Copyright:Copyright © 2015 by The American Association of Immunologists, Inc.