Cutting edge: T cell–dependent plasmablasts form in the absence of single differentiated CD4 + T cell subsets

Jessica A. Kotov, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The T follicular helper (Tfh) cell subset of CD4 + Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell–dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell–deficient mice produced as many PE-specific, isotype-switched plasmablasts as wild-type mice. This response depended on Th cell expression of CD154 and Ag presentation by B cells. These results indicate that many Th cell subsets can promote plasmablast formation by providing CD40 signals to naive B cells.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalJournal of Immunology
Volume202
Issue number2
DOIs
StatePublished - Jan 15 2019

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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