Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength

Karin M. Knudson, Sara E Hamilton Hart, Mark A. Daniels, Stephen C Jameson, Emma Teixeiro

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCRβ transmembrane domain mutant model that is defective in the generation of memory in response to high-affinity ligands. Surprisingly, lowering TCR signal strength, by stimulation with low-affinity ligands, resulted in normal memory development. Restoration of memory correlated with recovery of TCR-dependent NF-κB signaling. Thus, these data provide novel evidence that the requirements for memory are qualitatively different depending on TCR signal strength.

Original languageEnglish (US)
Pages (from-to)5797-5801
Number of pages5
JournalJournal of Immunology
Volume191
Issue number12
DOIs
StatePublished - Dec 15 2013

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