Cyclotrons and Radiopharmaceuticals in Positron Emission Tomography

George M. Bohigian; E. Harvey Estes; Ira Friedlander; William R. Kennedy; John H. Moxley; Patricia J. Numann; Paul S. Salva; William C. Scott; Joseph H. Skom; Richard M. Steinhilber; Jack P. Strong; Henry N. Wagner; William R. Hendee; William T. Mcgivney; Joanna S. Fowler; Edward J. Hoffman; Steven M. Larson; Heinrich R. Schelbert; Markus Schwaiger; Henry N. Wagner; Alfred P. Wolf; William R. Hendee

doi:10.1001/jama.1988.03720120058037

Cyclotrons and Radiopharmaceuticals in Positron Emission Tomography

George M. Bohigian, E. Harvey Estes, Ira Friedlander, William R. Kennedy, John H. Moxley, Patricia J. Numann, Paul S. Salva, William C. Scott, Joseph H. Skom, Richard M. Steinhilber, Jack P. Strong, Henry N. Wagner, William R. Hendee, William T. Mcgivney, Joanna S. Fowler, Edward J. Hoffman, Steven M. Larson, Heinrich R. Schelbert, Markus Schwaiger, Henry N. WagnerAlfred P. Wolf, William R. Hendee

Neurology

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15 Scopus citations

Abstract

Positron emission tomography (PET) can probe biochemical pathways in vivo and can provide quantitative data; for that purpose, tracers labeled with positron-emitting radioisotopes are essential. This report describes the tracers that are being used or that may have future use, their production by cyclotrons, and other needed resources for PET imaging. Current routine and automated methods for convenient production of labeled compounds, coupled with simple computer-controlled accelerators, can support the creation of clinical PET centers in any large medical institution, obviating the need for in-depth research teams. An alternate approach involves the development of regional centers that provide in-house service and that supply fluorine 18— and carbon 11—labeled compounds to nearby hospitals with PET machines.

Original language	English (US)
Pages (from-to)	1854-1860
Number of pages	7
Journal	JAMA: The Journal of the American Medical Association
Volume	259
Issue number	12
DOIs	https://doi.org/10.1001/jama.1988.03720120058037
State	Published - Mar 25 1988

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Bohigian, G. M., Estes, E. H., Friedlander, I., Kennedy, W. R., Moxley, J. H., Numann, P. J., Salva, P. S., Scott, W. C., Skom, J. H., Steinhilber, R. M., Strong, J. P., Wagner, H. N., Hendee, W. R., Mcgivney, W. T., Fowler, J. S., Hoffman, E. J., Larson, S. M., Schelbert, H. R., Schwaiger, M., ... Hendee, W. R. (1988). Cyclotrons and Radiopharmaceuticals in Positron Emission Tomography. JAMA: The Journal of the American Medical Association, 259(12), 1854-1860. https://doi.org/10.1001/jama.1988.03720120058037

Bohigian, GM, Estes, EH, Friedlander, I, Kennedy, WR, Moxley, JH, Numann, PJ, Salva, PS, Scott, WC, Skom, JH, Steinhilber, RM, Strong, JP, Wagner, HN, Hendee, WR, Mcgivney, WT, Fowler, JS, Hoffman, EJ, Larson, SM, Schelbert, HR, Schwaiger, M, Wagner, HN, Wolf, AP & Hendee, WR 1988, 'Cyclotrons and Radiopharmaceuticals in Positron Emission Tomography', JAMA: The Journal of the American Medical Association, vol. 259, no. 12, pp. 1854-1860. https://doi.org/10.1001/jama.1988.03720120058037

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AU - Estes, E. Harvey

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AU - Kennedy, William R.

AU - Moxley, John H.

AU - Numann, Patricia J.

AU - Salva, Paul S.

AU - Scott, William C.

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AU - Wagner, Henry N.

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AU - Mcgivney, William T.

AU - Fowler, Joanna S.

AU - Hoffman, Edward J.

AU - Larson, Steven M.

AU - Schelbert, Heinrich R.

AU - Schwaiger, Markus

AU - Wagner, Henry N.

AU - Wolf, Alfred P.

AU - Hendee, William R.

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Cyclotrons and Radiopharmaceuticals in Positron Emission Tomography

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