Deposition of silica agglomerates in a cast of human lung airways: Enhancement relative to spheres of equal mobility and aerodynamic diameter

Jacob H. Scheckman; Peter H. McMurry

doi:10.1016/j.jaerosci.2011.05.003

Deposition of silica agglomerates in a cast of human lung airways: Enhancement relative to spheres of equal mobility and aerodynamic diameter

Jacob H. Scheckman, Peter H. McMurry

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This paper reports on an experimental study of the deposition of well-characterized silica agglomerates in a cast of a section of a human lung. Deposition of the agglomerates is compared with the deposition of oleic acid spheres and sodium chloride particles for a range of mobility sizes, agglomerate properties (primary particle size and mass-mobility exponent) and inspiratory flow rates. In most cases, agglomerate deposition was significantly greater than that of the oleic acid and sodium chloride particles. Deposition of agglomerates with a more open structure was greater than that of relatively more compact (but still non-spherical) agglomerates. Deposition also increased with the flow rate. Because of the large physical size of the agglomerates, as well as the crenulated flow path through the model and the flow rate dependence, it is likely that interception is responsible for the enhanced deposition of the agglomerates.

Original language	English (US)
Pages (from-to)	508-516
Number of pages	9
Journal	Journal of Aerosol Science
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.jaerosci.2011.05.003
State	Published - Aug 2011

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation , Grant BES-0646507 . Electron microscopy was performed at the University of Minnesota College of Science and Engineering's Characterization Facility with the assistance of Dr. Lejun Qi and Ranganathan Gopalakrishnan. Dr. Michael Oldham, Community & Environmental Medicine, UC Irvine, generously provided the cast of the human lung section used in this study.

Keywords

Agglomerates
Fractal
Lung deposition
Mass
Mobility
Silica

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title = "Deposition of silica agglomerates in a cast of human lung airways: Enhancement relative to spheres of equal mobility and aerodynamic diameter",

abstract = "This paper reports on an experimental study of the deposition of well-characterized silica agglomerates in a cast of a section of a human lung. Deposition of the agglomerates is compared with the deposition of oleic acid spheres and sodium chloride particles for a range of mobility sizes, agglomerate properties (primary particle size and mass-mobility exponent) and inspiratory flow rates. In most cases, agglomerate deposition was significantly greater than that of the oleic acid and sodium chloride particles. Deposition of agglomerates with a more open structure was greater than that of relatively more compact (but still non-spherical) agglomerates. Deposition also increased with the flow rate. Because of the large physical size of the agglomerates, as well as the crenulated flow path through the model and the flow rate dependence, it is likely that interception is responsible for the enhanced deposition of the agglomerates.",

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N2 - This paper reports on an experimental study of the deposition of well-characterized silica agglomerates in a cast of a section of a human lung. Deposition of the agglomerates is compared with the deposition of oleic acid spheres and sodium chloride particles for a range of mobility sizes, agglomerate properties (primary particle size and mass-mobility exponent) and inspiratory flow rates. In most cases, agglomerate deposition was significantly greater than that of the oleic acid and sodium chloride particles. Deposition of agglomerates with a more open structure was greater than that of relatively more compact (but still non-spherical) agglomerates. Deposition also increased with the flow rate. Because of the large physical size of the agglomerates, as well as the crenulated flow path through the model and the flow rate dependence, it is likely that interception is responsible for the enhanced deposition of the agglomerates.

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Deposition of silica agglomerates in a cast of human lung airways: Enhancement relative to spheres of equal mobility and aerodynamic diameter

Abstract

Bibliographical note

Keywords

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