Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p<0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, β-CCP (p =0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, β-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 ± 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.
- Feeding behavior
- Gray wolf