Dielectrophoresis-enhanced plasmonic sensing with gold nanohole arrays

Avijit Barik, Lauren M. Otto, Daehan Yoo, Jincy Jose, Timothy W. Johnson, Sang Hyun Oh

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


We experimentally demonstrate dielectrophoretic concentration of biological analytes on the surface of a gold nanohole array, which concurrently acts as a nanoplasmonic sensor and gradient force generator. The combination of nanohole-enhanced dielectrophoresis, electroosmosis, and extraordinary optical transmission through the periodic gold nanohole array enables real-time label-free detection of analyte molecules in a 5 μL droplet using concentrations as low as 1 pM within a few minutes, which is more than 1000 times faster than purely diffusion-based binding. The nanohole-based optofluidic platform demonstrated here is straightforward to construct, applicable to both charged and neutral molecules, and performs a novel function that cannot be accomplished using conventional surface plasmon resonance sensors.

Original languageEnglish (US)
Pages (from-to)2006-2012
Number of pages7
JournalNano letters
Issue number4
StatePublished - Apr 9 2014


  • Optofluidics
  • dielectrophoresis
  • extraordinary optical transmission
  • mass transport
  • nanohole array
  • plasmonics
  • surface plasmon resonance


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